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Literature DB >> 10781793

A central role for the endothelial NADPH oxidase in atherosclerosis.

Abstract

An increasing body of evidence has demonstrated that NADPH oxidase plays a critical role in several early steps leading toward the development of atherosclerosis. These effects appear to be carried out by both the ability of O2- to act as a small second messenger molecule, and potentially the oxidation of low density lipoprotein by O2-. We describe a model for the initiation and development of atherosclerosis that suggests targeted inhibition of NADPH oxidase as a powerful site for prevention and treatment of this disease.

Entities: Chemical Disease

Mesh：

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Year: 2000 PMID： 10781793 DOI： 10.1016/s0014-5793(00)01397-1

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

21 in total

Review 1. Reactive oxygen intermediates involved in cellular regulation.

Authors: B Meier
Journal: Protoplasma Date: 2001 Impact factor: 3.356

2. Cross-talk between p(38)MAPK and G iα in regulating cPLA 2 activity by ET-1 in pulmonary smooth muscle cells.

Authors: Sajal Chakraborti; Animesh Chowdhury; Tapati Chakraborti
Journal: Mol Cell Biochem Date: 2014-11-16 Impact factor: 3.396

3. Aldosterone stimulates superoxide production in macula densa cells.

Authors: Xiaolong Zhu; R Davis Manning; Deyin Lu; Celso E Gomez-Sanchez; Yiling Fu; Luis A Juncos; Ruisheng Liu
Journal: Am J Physiol Renal Physiol Date: 2011-01-26

4. Hyperglycemia induces apoptosis and p53 mobilization to mitochondria in RINm5F cells.

Authors: C Ortega-Camarillo; A M Guzmán-Grenfell; R García-Macedo; A M Rosales-Torres; A Avalos-Rodríguez; G Durán-Reyes; R Medina-Navarro; M Cruz; M Díaz-Flores; J Kumate
Journal: Mol Cell Biochem Date: 2006-01 Impact factor: 3.396

Review 5. Lipid raft redox signaling platforms in vascular dysfunction: features and mechanisms.

Authors: Si Jin; Fan Zhou
Journal: Curr Atheroscler Rep Date: 2009-05 Impact factor: 5.113

6. Cross-talk between NADPH oxidase-PKCα-p(38)MAPK and NF-κB-MT1MMP in activating proMMP-2 by ET-1 in pulmonary artery smooth muscle cells.

Authors: Jaganmay Sarkar; Animesh Chowdhury; Tapati Chakraborti; Sajal Chakraborti
Journal: Mol Cell Biochem Date: 2016-02-24 Impact factor: 3.396

A central role for the endothelial NADPH oxidase in atherosclerosis.

Review 1. Reactive oxygen intermediates involved in cellular regulation.

2. Cross-talk between p(38)MAPK and G iα in regulating cPLA 2 activity by ET-1 in pulmonary smooth muscle cells.

3. Aldosterone stimulates superoxide production in macula densa cells.

4. Hyperglycemia induces apoptosis and p53 mobilization to mitochondria in RINm5F cells.

Review 5. Lipid raft redox signaling platforms in vascular dysfunction: features and mechanisms.

6. Cross-talk between NADPH oxidase-PKCα-p(38)MAPK and NF-κB-MT1MMP in activating proMMP-2 by ET-1 in pulmonary artery smooth muscle cells.

7. Expression of NADPH oxidase isoform 1 (Nox1) in human placenta: involvement in preeclampsia.

8. Lipopolysaccharide-induced alterations in oxygen consumption and radical generation in endothelial cells.

9. Polyunsaturated fatty acids modulate NOX 4 anion superoxide production in human fibroblasts.

10. Critical role of lipid raft redox signaling platforms in endostatin-induced coronary endothelial dysfunction.