| Literature DB >> 10781405 |
Abstract
Transcriptional control of T cell development is a complex and rapidly moving area of investigation. Recent advances reveal critical roles for several transcription factors in T cell commitment, differentiation and selection. In particular, new roles for E proteins as well as members of the Notch signaling pathway have been described. Additionally, a unique function of Ikaros in chromatin remodeling reveals a novel mechanism by which transcriptional control may be exerted.Entities:
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Year: 2000 PMID: 10781405 DOI: 10.1016/s0952-7915(00)00091-1
Source DB: PubMed Journal: Curr Opin Immunol ISSN: 0952-7915 Impact factor: 7.486