Literature DB >> 10781403

Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo.

J A Trapani1, J Davis, V R Sutton, M J Smyth.   

Abstract

Recent advances in our understanding of cytolytic effector mechanisms include the partial characterization of caspase-independent apoptotic pathways triggered by granzymes, a realization of the vital importance of perforin and granzymes in the defence against certain virus infections in vivo and the first description of hereditary immunodeficiency due to disordered perforin expression in humans.

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Year:  2000        PMID： 10781403     DOI： 10.1016/s0952-7915(00)00094-7

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  23 in total

1.  Expansion of CD4+ T cells with a cytotoxic phenotype in patients with B-chronic lymphocytic leukaemia (B-CLL).

Authors:  N Porakishvili; T Roschupkina; T Kalber; A P Jewell; K Patterson; K Yong; P M Lydyard
Journal:  Clin Exp Immunol       Date:  2001-10       Impact factor: 4.330

2.  The diverse roles of the TNF axis in cancer progression and metastasis.

Authors:  Boram Ham; Maria Celia Fernandez; Zarina D'Costa; Pnina Brodt
Journal:  Trends Cancer Res       Date:  2016-01-01

3.  Interaction among smoking status, single nucleotide polymorphisms and markers of systemic inflammation in healthy individuals.

Authors:  Thitiya Luetragoon; Lars E Rutqvist; Orathai Tangvarasittichai; Bengt-Åke Andersson; Sture Löfgren; Kanchana Usuwanthim; Nongnit L Lewin
Journal:  Immunology       Date:  2018-01-02       Impact factor: 7.397

4.  Perforin, CD28 and CD95 expression in circulating CD4 and CD8 cells as predictors of head and neck (H&N) cancer patient survival.

Authors:  Nongnit Laytragoon-Lewin; Fredrik Jönson; Jan Lundgren; Lars Erik Rutqvist; Anders Wikby; Sture Löfgren; Freddi Lewin
Journal:  Med Oncol       Date:  2014-10-25       Impact factor: 3.064

5.  Regulation of IFN-gamma signaling is essential for the cytotoxic activity of CD8(+) T cells.

Authors:  G Z Tau; S N Cowan; J Weisburg; N S Braunstein; P B Rothman
Journal:  J Immunol       Date:  2001-11-15       Impact factor: 5.422

6.  Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors.

Authors:  J P Medema; J de Jong; L T Peltenburg; E M Verdegaal; A Gorter; S A Bres; K L Franken; M Hahne; J P Albar; C J Melief; R Offringa
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-18       Impact factor: 11.205

7.  Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice.

Authors:  Ashutosh K Mangalam; David Luckey; Shailendra Giri; Michele Smart; Larry R Pease; Moses Rodriguez; Chella S David
Journal:  J Autoimmun       Date:  2012-03-28       Impact factor: 7.094

Review 8.  Anti-interleukin-2 receptor antibodies for the prevention of rejection in pediatric renal transplant patients: current status.

Authors:  Agnieszka Swiatecka-Urban
Journal:  Paediatr Drugs       Date:  2003       Impact factor: 3.022

9.  Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells.

Authors:  Suresh Chava; Suresh Bugide; Romi Gupta; Narendra Wajapeyee
Journal:  J Vis Exp       Date:  2020-02-22       Impact factor: 1.355

Review 10.  NK cell-based immunotherapy for malignant diseases.

Authors:  Min Cheng; Yongyan Chen; Weihua Xiao; Rui Sun; Zhigang Tian
Journal:  Cell Mol Immunol       Date:  2013-04-22       Impact factor: 11.530
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