Literature DB >> 10780412

Synthesis of 4'-substituted nucleosides and their biological evaluation.

S Kohgo1, E Kodama, S Shigeta, M Saneyoshi, H Machida, H Ohrui.   

Abstract

4'-C-Ethynyl-beta-D-arabino- and 4'-C-ethynyl-beta-D-2'-deoxy-ribo-pentofuranosyl pyrimidines were synthesized. Most of these 4'-ethynyl nucleosides showed interesting biological activities.

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Year:  1999        PMID： 10780412     DOI： 10.1093/nass/42.1.127

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser        ISSN： 0261-3166


  4 in total

1.  4'-modified nucleoside analogs: potent inhibitors active against entecavir-resistant hepatitis B virus.

Authors:  Yuki Takamatsu; Yasuhito Tanaka; Satoru Kohgo; Shuko Murakami; Kamalendra Singh; Debananda Das; David J Venzon; Masayuki Amano; Nobuyo Higashi-Kuwata; Manabu Aoki; Nicole S Delino; Sanae Hayashi; Satoru Takahashi; Yoshikazu Sukenaga; Kazuhiro Haraguchi; Stefan G Sarafianos; Kenji Maeda; Hiroaki Mitsuya
Journal:  Hepatology       Date:  2015-08-25       Impact factor: 17.425

2.  The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase.

Authors:  Yuki Takamatsu; Debananda Das; Satoru Kohgo; Hironori Hayashi; Nicole S Delino; Stefan G Sarafianos; Hiroaki Mitsuya; Kenji Maeda
Journal:  Cell Chem Biol       Date:  2018-08-30       Impact factor: 8.116

3.  7-Deaza-7-fluoro modification confers on 4'-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety.

Authors:  Sanae Hayashi; Nobuyo Higashi-Kuwata; Debananda Das; Kota Tomaya; Kohei Yamada; Shuko Murakami; David J Venzon; Shin-Ichiro Hattori; Masanori Isogawa; Stefan G Sarafianos; Hiroaki Mitsuya; Yasuhito Tanaka
Journal:  Antiviral Res       Date:  2020-02-18       Impact factor: 5.970

4.  Development of modified nucleosides that have supremely high anti-HIV activity and low toxicity and prevent the emergence of resistant HIV mutants.

Authors:  Hiroshi Ohrui
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2011       Impact factor: 3.493
  4 in total

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