| Literature DB >> 10780396 |
N Sugimoto1, K Yamamoto, N Satoh.
Abstract
We report positional effect of bulge nucleotide on PNA/DNA hybrid stability. CD spectra showed that PNA/DNA hybrids required at least seven base pairings at a stem region to form a bulged structure. On the other hand, DNA/DNA could form bulged structure when there are only four base pairings adjacent to the bulge nucleotide. We discuss why PNA requests such a many base pairings to form bulged structure from a nearest neighbor standpoint.Mesh：
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Year: 1999 PMID： 10780396 DOI： 10.1093/nass/42.1.95
Source DB: PubMed Journal: Nucleic Acids Symp Ser ISSN： 0261-3166