Literature DB >> 10780375

The interaction of benzimidazole compounds with DNA: intercalation and groove binding modes.

Y Kubota1, T Iwamoto, T Seki.   

Abstract

Benzimidazole compounds (Fig. 1) have been synthesized to study their DNA-binding properties. Results obtained with spectroscopy and viscosity measurements indicate that the binding mode varies from intercalation to groove-binding, depending on the number of benzimidazole rings (conformation and size of compounds).

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Year:  1999        PMID: 10780375     DOI: 10.1093/nass/42.1.53

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser        ISSN: 0261-3166


  2 in total

1.  Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer.

Authors:  Le Zhang; Milana Bochkur Dratver; Taha Yazal; Kevin Dong; Andrea Nguyen; Garrett Yu; Amy Dao; Michael Bochkur Dratver; Sara Duhachek-Muggy; Kruttika Bhat; Claudia Alli; Frank Pajonk; Erina Vlashi
Journal:  Int J Radiat Oncol Biol Phys       Date:  2018-09-07       Impact factor: 7.038

2.  Conjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic properties.

Authors:  Zena A Al-Mudaris; Aman S A Majid; Dan Ji; Ban A Al-Mudarris; Shih-Hsun Chen; Po-Huang Liang; Hasnah Osman; Shah Kamal Khan Jamal Din; Amin M S Abdul Majid
Journal:  PLoS One       Date:  2013-11-15       Impact factor: 3.240

  2 in total

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