| Literature DB >> 10777763 |
Y E Korchev1, M Raval, M J Lab, J Gorelik, C R Edwards, T Rayment, D Klenerman.
Abstract
We have developed a hybrid scanning ion conductance and scanning near-field optical microscope for the study of living cells. The technique allows quantitative, high-resolution characterization of the cell surface and the simultaneous recording of topographic and optical images. A particular feature of the method is a reliable mechanism to control the distance between the probe and the sample in physiological buffer. We demonstrate this new method by recording near-field images of living cells (cardiac myocytes).Mesh:
Substances:
Year: 2000 PMID: 10777763 PMCID: PMC1300856 DOI: 10.1016/S0006-3495(00)76811-1
Source DB: PubMed Journal: Biophys J ISSN: 0006-3495 Impact factor: 4.033