| Literature DB >> 10777247 |
A Bernhoft1, J U Skaare, O Wiig, A E Derocher, H J Larsen.
Abstract
Associations between immunoglobulin G (IgG) levels and the organochlorine contaminants (OCs) polychlorinated biphenyls (PCBs), chlordanes, 1,1-dichloro-2,2-bis(4-chlorophenyl) ethylene (DDE), hexachlorobenzene (HCB), and hexachlorocyclohexanes (HCHs) in blood plasma from polar bears caught at Svalbard were determined. The blood samples were collected from free-living polar bears of different age and sex between 1991 and 1994. The IgC concentration increased with age and was significantly higher in males than in females. IgG was negatively correlated with sigmaPCB level and with three individual PCB congeners, IUPAC numbers 99, 194, and 206. HCB was also negatively correlated with IgG. The significant negative OC correlation with IgG levels may indicate an immunotoxic effect.Entities:
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Year: 2000 PMID： 10777247 DOI： 10.1080/009841000156682
Source DB: PubMed Journal: J Toxicol Environ Health A ISSN： 0098-4108