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Literature DB >> 10774727

The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans.

G Cassata¹, H Kagoshima, Y Andachi, Y Kohara, M B Dürrenberger, D H Hall, T R Bürglin.

Abstract

In Caenorhabditis elegans three pairs of neurons, AFD, AIY, and AIZ, play a key role in thermosensation. The LIM homeobox gene ceh-14 is expressed in the AFD thermosensory neurons. ceh-14 mutant animals display athermotactic behaviors, although the neurons are still present and differentiated. Two other LIM homeobox genes, ttx-3 and lin-11, function in the two interneurons AIY and AIZ, respectively. Thus, the three key thermosensory neurons are specified by three different LIM homeobox genes. ceh-14 ttx-3 lin-11 triple mutant animals have a basic cryophilic thermotaxis behavior indicative of a second thermotaxis pathway. Misexpression of ceh-14 in chemosensory neurons can restore thermotactic behavior without impairing the chemosensory function. Thus, ceh-14 confers thermosensory function to neurons.

Entities: Disease Gene Species

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Year: 2000 PMID： 10774727 DOI： 10.1016/s0896-6273(00)81062-4

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

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Cited

29 in total

1. Synaptic activity of the AFD neuron in Caenorhabditis elegans correlates with thermotactic memory.

Authors: Aravinthan D T Samuel; Ruwan A Silva; Venkatesh N Murthy
Journal: J Neurosci Date: 2003-01-15 Impact factor: 6.167

Review 2. Temperature sensing across species.

Authors: David D McKemy
Journal: Pflugers Arch Date: 2007-01-12 Impact factor: 3.657

The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans.

1. Synaptic activity of the AFD neuron in Caenorhabditis elegans correlates with thermotactic memory.

Review 2. Temperature sensing across species.

3. Rapid sequence evolution of transcription factors controlling neuron differentiation in Caenorhabditis.

4. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis.

5. A competition mechanism for a homeotic neuron identity transformation in C. elegans.

6. The forkhead domain gene unc-130 generates chemosensory neuron diversity in C. elegans.

7. Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans.

8. Transcription factor modularity in a gene-centered C. elegans core neuronal protein-DNA interaction network.

9. Modular control of glutamatergic neuronal identity in C. elegans by distinct homeodomain proteins.

10. Early evolution of the LIM homeobox gene family.