AIMS AND BACKGROUND: Non-melanocytic skin cancers are the most common cancers in white populations. Studies on populations of Anglo-Saxon and Mediterranean origins highlighted different patterns of risk of basal-cell carcinoma and squamous-cell carcinoma in relation to sunlight exposure, skin characteristics and phenotype susceptibility. In Sion, and in Switzerland as a whole, the high incidence suggests the possible presence of additional risk factors or of a different pattern of exposure to solar radiation as well as different composition of pigmentary traits and skin sensitivity to sun. METHODS AND STUDY DESIGN: We conducted a case-control study of 146 cases (73% of eligible cases) and 144 controls (81% of eligible subjects) to further evaluate the relationship between nonmelanocytic skin cancer and risk factors in the Sion population. Interviews were conducted by trained interviewers with a standardized questionnaire. RESULTS: Pigmentary characteristics such as blonde and red hair as well as tendency to sunburn without tanning and number of sunburns showed a statistically significant and independent risk increase in basal-cell carcinoma. Sun exposure during recreational activities (outdoor sports) showed a risk increase in basal-cell carcinoma with borderline statistical significance. Analysis of squamous-cell carcinoma risk was limited by the small number of cases, but it was positively associated with lifetime exposure to sun during outdoor work and with skin characteristics. CONCLUSIONS: Results confirmed previous suggestions of a different mechanism leading to malignant transformation of target cells from the basal and squamous epidermal layers, mediated by different phenotypes, and conditioning the ability to develop an effectively protective tan.
AIMS AND BACKGROUND: Non-melanocytic skin cancers are the most common cancers in white populations. Studies on populations of Anglo-Saxon and Mediterranean origins highlighted different patterns of risk of basal-cell carcinoma and squamous-cell carcinoma in relation to sunlight exposure, skin characteristics and phenotype susceptibility. In Sion, and in Switzerland as a whole, the high incidence suggests the possible presence of additional risk factors or of a different pattern of exposure to solar radiation as well as different composition of pigmentary traits and skin sensitivity to sun. METHODS AND STUDY DESIGN: We conducted a case-control study of 146 cases (73% of eligible cases) and 144 controls (81% of eligible subjects) to further evaluate the relationship between nonmelanocytic skin cancer and risk factors in the Sion population. Interviews were conducted by trained interviewers with a standardized questionnaire. RESULTS: Pigmentary characteristics such as blonde and red hair as well as tendency to sunburn without tanning and number of sunburns showed a statistically significant and independent risk increase in basal-cell carcinoma. Sun exposure during recreational activities (outdoor sports) showed a risk increase in basal-cell carcinoma with borderline statistical significance. Analysis of squamous-cell carcinoma risk was limited by the small number of cases, but it was positively associated with lifetime exposure to sun during outdoor work and with skin characteristics. CONCLUSIONS: Results confirmed previous suggestions of a different mechanism leading to malignant transformation of target cells from the basal and squamous epidermal layers, mediated by different phenotypes, and conditioning the ability to develop an effectively protective tan.
Authors: M Murphy; M J E M F Mabruk; P Lenane; A Liew; P McCann; A Buckley; C O Flatharta; D Hevey; P Billet; W Robertson; S Javed; M Leader; E Kay; G M Murphy Journal: J Clin Pathol Date: 2002-11 Impact factor: 3.411
Authors: Margaret R Karagas; M Scot Zens; Zhigang Li; Therese A Stukel; Ann E Perry; Diane Gilbert-Diamond; Vicki Sayarath; Rita S Stephenson; Dorothea Barton; Heather H Nelson; Steven K Spencer Journal: Pediatrics Date: 2014-07 Impact factor: 7.124
Authors: Leah M Ferrucci; Brenda Cartmel; Annette M Molinaro; David J Leffell; Allen E Bale; Susan T Mayne Journal: J Am Acad Dermatol Date: 2011-12-09 Impact factor: 11.527
Authors: Peter A Andersen; David B Buller; Barbara J Walkosz; Michael D Scott; Ilima L Kane; Gary R Cutter; Mark B Dignan; Xia Liu Journal: Transl Behav Med Date: 2012-03 Impact factor: 3.046
Authors: A Bauer; E Haufe; L Heinrich; A Seidler; H J Schulze; P Elsner; H Drexler; S Letzel; S M John; M Fartasch; T Brüning; S Dugas-Breit; M Gina; W Weistenhöfer; K Bachmann; I Bruhn; B M Lang; R Brans; J P Allam; W Grobe; S Westerhausen; P Knuschke; M Wittlich; T L Diepgen; J Schmitt Journal: J Occup Med Toxicol Date: 2020-09-10 Impact factor: 2.646
Authors: Berta Suárez; Gonzalo López-Abente; Carmen Martínez; Carmen Navarro; Maria José Tormo; Stefano Rosso; Simon Schraub; Lorenzo Gafà; Hélène Sancho-Garnier; Janine Wechsler; Roberto Zanetti Journal: BMC Public Health Date: 2007-07-26 Impact factor: 3.295