M Sadat-Ali1, I al-Habdan, A al-Othman. 1. Department of Orthopedic Surgery, King Fadh University Hospital, Al-Khobar, Saudi Arabia.
Abstract
BACKGROUND: Although the cause of adolescent idiopathic scoliosis remains unclear, pinealectomy is followed by the development of scoliosis in chickens. Melatonin is the only hormone secreted by pineal gland. OBJECTIVE: To assess serum melatonin levels in adolescents with idiopathic scoliosis. METHODS: Serum melatonin was assayed once, at 12:00 hours, in each of 20 adolescents with idiopathic scoliosis and 10 age-matched siblings. In the patient group, mean age was 14.3 years and the mean Cobb angle was 54.5 degrees (range, 20 degrees-110 degrees). Mean age in the control group was 14 years. RESULTS: Serum melatonin was significantly lower in the patients (mean, 7.7 pg/mL; range, 4 to 13 pg/mL) than in the controls (mean, 29.9 pg/mL; range, 19.3 to 46 pg/mL) (P < 0.00001). The 12 surgically treated patients had a mean melatonin level of 8.1 pg/mL, versus 7.2 pg/mL in the eight other patients (nonsignificant P and regression coefficient values). Serum melatonin was not significantly correlated with the Cobb's angle (regression coefficient, 0.18; P < 0.44). CONCLUSION: Our data suggest that serum melatonin levels may contribute to the pathogenesis of idiopathic scoliosis.
BACKGROUND: Although the cause of adolescent idiopathic scoliosis remains unclear, pinealectomy is followed by the development of scoliosis in chickens. Melatonin is the only hormone secreted by pineal gland. OBJECTIVE: To assess serum melatonin levels in adolescents with idiopathic scoliosis. METHODS: Serum melatonin was assayed once, at 12:00 hours, in each of 20 adolescents with idiopathic scoliosis and 10 age-matched siblings. In the patient group, mean age was 14.3 years and the mean Cobb angle was 54.5 degrees (range, 20 degrees-110 degrees). Mean age in the control group was 14 years. RESULTS: Serum melatonin was significantly lower in the patients (mean, 7.7 pg/mL; range, 4 to 13 pg/mL) than in the controls (mean, 29.9 pg/mL; range, 19.3 to 46 pg/mL) (P < 0.00001). The 12 surgically treated patients had a mean melatonin level of 8.1 pg/mL, versus 7.2 pg/mL in the eight other patients (nonsignificant P and regression coefficient values). Serum melatonin was not significantly correlated with the Cobb's angle (regression coefficient, 0.18; P < 0.44). CONCLUSION: Our data suggest that serum melatonin levels may contribute to the pathogenesis of idiopathic scoliosis.
Authors: A Moreau; M-Y Akoumé Ndong; B Azeddine; A Franco; P H Rompré; M-H Roy-Gagnon; I Turgeon; D Wang; K M Bagnall; B Poitras; H Labelle; C-H Rivard; G Grimard; J Ouellet; S Parent; F Moldovan Journal: Orthopade Date: 2009-02 Impact factor: 1.087
Authors: Gene Chi Wai Man; Man Gene Chi Wai; William Wei Jun Wang; Wang William Wei Jun; Annie Po Yee Yim; Yim Annie Po Yee; Jack Ho Wong; Wong Jack Ho; Tzi Bun Ng; Ng Tzi Bun; Tsz Ping Lam; Lam Tsz Ping; Simon Kwong Man Lee; Lee Simon Kwong Man; Bobby Kin Wah Ng; Ng Bobby Kin Wah; Chi Chiu Wang; Wang Chi Chiu; Yong Qiu; Qiu Yong; Chun Yiu Cheng; Cheng Jack Chun Yiu Journal: Int J Mol Sci Date: 2014-09-18 Impact factor: 5.923