Literature DB >> 10773544

Synthesis of 8-[(18)F]fluoroguanine derivatives: in vivo probes for imaging gene expression with positron emission tomography.

M Namavari1, J R Barrio, T Toyokuni, S S Gambhir, S R Cherry, H R Herschman, M E Phelps, N Satyamurthy1.   

Abstract

A new method for the preparation of 8-[(18)F]fluoroguanine derivatives based on a direct radiofluorination reaction has been developed. The radiofluorination of ganciclovir (1a) with [(18)F]F(2) was carried out in absolute ethanol in the presence of tetraethylammonium hydroxide at room temperature to give 8-[(18)F]fluoroganciclovir (3a) in an approximately 1% radiochemical yield. Similarly, 8-[(18)F]fluoropenciclovir (3b), 8-[(18)F]fluoroacyclovir (3c), and 8-[(18)F]fluoroguanosine (3d) were synthesized from penciclovir (1b), acyclovir (1c), and guanosine (1d), respectively, using [(18)F]F(2). The structural analyses of the final products (3a, 3b, 3c, and 3d) were carried out after (18)F decay by (1)H, (13)C, and (19)F nuclear magnetic resonance and high resolution mass spectroscopy.

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Year:  2000        PMID： 10773544     DOI： 10.1016/s0969-8051(99)00095-5

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  8 in total

Review 1.  Imaging transgene expression with radionuclide imaging technologies.

Authors:  S S Gambhir; H R Herschman; S R Cherry; J R Barrio; N Satyamurthy; T Toyokuni; M E Phelps; S M Larson; J Balatoni; R Finn; M Sadelain; J Tjuvajev; R Blasberg
Journal:  Neoplasia       Date:  2000 Jan-Apr       Impact factor: 5.715

Review 2.  Molecular imaging: a view from the inside.

Authors:  Harvey R Herschman
Journal:  J Nucl Cardiol       Date:  2004 Mar-Apr       Impact factor: 5.952

3.  (99m)Tc-EC-guanine: synthesis, biodistribution, and tumor imaging in animals.

Authors:  David J Yang; Kaoru Ozaki; Chang-Sok Oh; Ali Azhdarinia; Thomas Yang; Megumi Ito; Allison Greenwell; Jerry Bryant; Saady Kohanim; Vincenzo K Wong; E Edmund Kim
Journal:  Pharm Res       Date:  2005-08-24       Impact factor: 4.200

4.  Efficient radiosynthesis of 2-[(18)f]fluoroadenosine: a new route to 2-[(18)f]fluoropurine nucleosides.

Authors:  Patrice Marchand; Christophe Lorilleux; Gwénaëlle Gilbert; Fabienne Gourand; Franck Sobrio; Damien Peyronnet; Martine Dhilly; Louisa Barré
Journal:  ACS Med Chem Lett       Date:  2010-05-28       Impact factor: 4.345

5.  Synthesis of 2'-deoxy-2'-[18F]fluoro-9-β-D-arabinofuranosylguanine: a novel agent for imaging T-cell activation with PET.

Authors:  Mohammad Namavari; Ya-Fang Chang; Brenda Kusler; Shahriar Yaghoubi; Beverly S Mitchell; Sanjiv Sam Gambhir
Journal:  Mol Imaging Biol       Date:  2011-10       Impact factor: 3.488

6.  Positron emission tomography provides molecular imaging of biological processes.

Authors:  M E Phelps
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

7.  Positron emission tomography (PET) imaging with (18)F-based radiotracers.

Authors:  Mian M Alauddin
Journal:  Am J Nucl Med Mol Imaging       Date:  2011-12-15

8.  In vivo evaluation of 2'-deoxy-2'-[(18)F]fluoro-5-iodo-1-beta-D-arabinofuranosyluracil ([18F]FIAU) and 2'-deoxy-2'-[18F]fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil ([18F]FEAU) as markers for suicide gene expression.

Authors:  Mian M Alauddin; Antranic Shahinian; Ryan Park; Michel Tohme; John D Fissekis; Peter S Conti
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-01-06       Impact factor: 10.057
  8 in total

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