| Literature DB >> 10773417 |
K Fassbender1, S Schneider, T Bertsch, D Schlueter, M Fatar, A Ragoschke, S Kühl, U Kischka, M Hennerici.
Abstract
Timing and extent of trauma-induced release of interleukin-1beta (IL-1beta) in extracellular fluid of the CNS were analyzed. In brain tissue perfusates obtained by in vivo microdialysis a marked release of IL-1beta was unexpectedly detected within less than 60 min. At such an early stage of neurotrauma, mRNA expression of IL-1beta was detected whereas immunoreactivity for the IL-1beta protein was negative. Concentrations of extracellularly secreted IL-1beta protein gradually increased, peaked at day 2 and decreased thereafter. Drugs acting on mononuclear phagocytes significantly modulated IL-1beta secretion. This so far unrecognized acuity of IL-1beta release demonstrated here, may represent a precondition for the orchestrating role of this mediator in the cascade of inflammatory host response.Entities:
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Year: 2000 PMID： 10773417 DOI： 10.1016/s0304-3940(00)00977-0
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046