Literature DB >> 10773406

Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice.

M Jojovic1, U Schumacher.   

Abstract

The number of spontaneous lung metastases of the human colon cancer cell line HT29 transplanted into SCID mice was quantified. The lungs were sliced, randomly distributed in agar blocks and the number of lung metastases was counted for each of 39 animals. A nearly exponential increase of metastases with weight of the tumor at the implantation site was observed. This suggests that a critical tumor weight for the initiation of metastatic spread exists. Calculating the data, a simplified quantitative assessment of the metastatic load by counting ten histological sections only for the estimation of the total number of lung metastases is proposed.

Entities:  

Mesh：

Year:  2000        PMID： 10773406     DOI： 10.1016/s0304-3835(99)00443-7

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  18 in total

1.  Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow-derived monocyte polarization.

Authors:  Elizabeth F Redente; Lori D Dwyer-Nield; Daniel T Merrick; Komal Raina; Rajesh Agarwal; William Pao; Pamela L Rice; Kenneth R Shroyer; Alvin M Malkinson
Journal:  Am J Pathol       Date:  2010-04-29       Impact factor: 4.307

2.  Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.

Authors:  Sabine Windhorst; Ralf Fliegert; Christine Blechner; Katharina Möllmann; Zara Hosseini; Thomas Günther; Maike Eiben; Lydia Chang; Hong-Ying Lin; Werner Fanick; Udo Schumacher; Burkhard Brandt; Georg W Mayr
Journal:  J Biol Chem       Date:  2009-12-17       Impact factor: 5.157

3.  Cell adhesion molecules in metastatic neuroblastoma models.

Authors:  Nina Schwankhaus; Christina Gathmann; Daniel Wicklein; Kristoffer Riecken; Udo Schumacher; Ursula Valentiner
Journal:  Clin Exp Metastasis       Date:  2014-02-19       Impact factor: 5.150

4.  Quantification of human Alu sequences by real-time PCR--an improved method to measure therapeutic efficacy of anti-metastatic drugs in human xenotransplants.

Authors:  Tanja Schneider; Franz Osl; Thomas Friess; Hubertus Stockinger; Werner V Scheuer
Journal:  Clin Exp Metastasis       Date:  2002       Impact factor: 5.150

5.  Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung.

Authors:  Tatyana Kalinina; Cenap Güngör; Sabrina Thieltges; Maren Möller-Krull; Eva Maria Murga Penas; Daniel Wicklein; Thomas Streichert; Udo Schumacher; Viacheslav Kalinin; Ronald Simon; Benjamin Otto; Judith Dierlamm; Heidi Schwarzenbach; Katharina E Effenberger; Maximilian Bockhorn; Jakob R Izbicki; Emre F Yekebas
Journal:  BMC Cancer       Date:  2010-06-16       Impact factor: 4.430

6.  Clinically proven markers of metastasis predict metastatic spread of human melanoma cells engrafted in scid mice.

Authors:  A Thies; S Mauer; O Fodstad; U Schumacher
Journal:  Br J Cancer       Date:  2007-01-30       Impact factor: 7.640

7.  E-/P-selectins and colon carcinoma metastasis: first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung.

Authors:  S Köhler; S Ullrich; U Richter; U Schumacher
Journal:  Br J Cancer       Date:  2009-12-15       Impact factor: 7.640

8.  Low-dose mistletoe lectin-I reduces melanoma growth and spread in a scid mouse xenograft model.

Authors:  A Thies; P Dautel; A Meyer; U Pfüller; U Schumacher
Journal:  Br J Cancer       Date:  2007-11-20       Impact factor: 7.640

9.  c-FOS suppresses ovarian cancer progression by changing adhesion.

Authors:  L Oliveira-Ferrer; K Rößler; V Haustein; C Schröder; D Wicklein; D Maltseva; N Khaustova; T Samatov; A Tonevitsky; S Mahner; F Jänicke; U Schumacher; K Milde-Langosch
Journal:  Br J Cancer       Date:  2013-12-05       Impact factor: 7.640

10.  Selectins mediate small cell lung cancer systemic metastasis.

Authors:  Franziska Heidemann; Anna Schildt; Katharina Schmid; Oliver T Bruns; Kristoffer Riecken; Caroline Jung; Harald Ittrich; Daniel Wicklein; Rudolph Reimer; Boris Fehse; Joerg Heeren; Georg Lüers; Udo Schumacher; Markus Heine
Journal:  PLoS One       Date:  2014-04-03       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.