OBJECTIVES: To evaluate the relationship of memory decline that accompanies aging with structural changes in the medial temporal lobe, in healthy middle-aged and older subjects. MATERIAL AND METHODS: A sample of 35 neurologically non-diseased subjects, between 55 and 70 years of age, were examined in a 5-year follow-up study. Neuropsychological investigation included tests of learning, verbal memory, and visual memory. MRI was performed with a superconducting MRI system operating at 1.0 T, using coronal slices of T1-weighted images. Medial temporal lobe atrophy was rated separately in the neocortical, entorhinal and hippocampal regions. RESULTS: We did not find any statistically significant relationship between mild hippocampal or temporal atrophy and memory test performance. Nor did the longitudinal decline in memory show a relationship with temporal lobe atrophy. CONCLUSIONS: The main outcome of our study was that age-related memory decline was not related to mild temporal lobe atrophy in healthy subjects without mild cognitive impairment. There could be other factors influencing memory functions besides age-related structural changes in temporal lobes.
OBJECTIVES: To evaluate the relationship of memory decline that accompanies aging with structural changes in the medial temporal lobe, in healthy middle-aged and older subjects. MATERIAL AND METHODS: A sample of 35 neurologically non-diseased subjects, between 55 and 70 years of age, were examined in a 5-year follow-up study. Neuropsychological investigation included tests of learning, verbal memory, and visual memory. MRI was performed with a superconducting MRI system operating at 1.0 T, using coronal slices of T1-weighted images. Medial temporal lobe atrophy was rated separately in the neocortical, entorhinal and hippocampal regions. RESULTS: We did not find any statistically significant relationship between mild hippocampal or temporal atrophy and memory test performance. Nor did the longitudinal decline in memory show a relationship with temporal lobe atrophy. CONCLUSIONS: The main outcome of our study was that age-related memory decline was not related to mild temporal lobe atrophy in healthy subjects without mild cognitive impairment. There could be other factors influencing memory functions besides age-related structural changes in temporal lobes.
Authors: Joel H Kramer; Dan Mungas; Bruce R Reed; Margaret E Wetzel; Molly M Burnett; Bruce L Miller; Michael W Weiner; Helena C Chui Journal: Neuropsychology Date: 2007-07 Impact factor: 3.295
Authors: Linda L Chao; Shannon T Buckley; John Kornak; Norbert Schuff; Catherine Madison; Kristine Yaffe; Bruce L Miller; Joel H Kramer; Michael W Weiner Journal: Alzheimer Dis Assoc Disord Date: 2010 Jan-Mar Impact factor: 2.703
Authors: Liana G Apostolova; Jonathan H Morra; Amity E Green; Kristy S Hwang; Christina Avedissian; Ellen Woo; Jeffrey L Cummings; Arthur W Toga; Clifford R Jack; Michael W Weiner; Paul M Thompson Journal: Neuroimage Date: 2010-01-18 Impact factor: 6.556
Authors: Valentina Pergher; Philippe Demaerel; Olivier Soenen; Carina Saarela; Jos Tournoy; Birgitte Schoenmakers; Mira Karrasch; Marc M Van Hulle Journal: Neuroimage Clin Date: 2019-02-05 Impact factor: 4.881