Literature DB >> 10769010

Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi.

S Babu1, L M Ganley, T R Klei, L D Shultz, T V Rajan.   

Abstract

We have investigated the roles of gamma interferon (IFN-gamma) and interleukin-4 (IL-4) in host defense against Brugia malayi. Our data suggest that the lack of either IFN-gamma or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in the clearance of infection.

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Year:  2000        PMID： 10769010      PMCID： PMC97525          DOI： 10.1128/IAI.68.5.3034-3035.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  4 in total

1.  Infectivity and normal development of third stage Brugia malayi maintained in vitro.

Authors:  J A Yates; K A Schmitz; F K Nelson; T V Rajan
Journal:  J Parasitol       Date:  1994-12       Impact factor: 1.276

Review 2.  Strategies and tools for the control/elimination of lymphatic filariasis.

Authors:  E A Ottesen; B O Duke; M Karam; K Behbehani
Journal:  Bull World Health Organ       Date:  1997       Impact factor: 9.408

Review 3.  The regulation of immunity to Leishmania major.

Authors:  S L Reiner; R M Locksley
Journal:  Annu Rev Immunol       Date:  1995       Impact factor: 28.527

4.  Infection of IL-4-deficient mice with the parasitic nematode Brugia malayi demonstrates that host resistance is not dependent on a T helper 2-dominated immune response.

Authors:  R A Lawrence; J E Allen; W F Gregory; M Kopf; R M Maizels
Journal:  J Immunol       Date:  1995-06-01       Impact factor: 5.422
  4 in total
  27 in total

1.  Update on Lymphatic Filarial Infections.

Authors:  Paul B. Keiser; Thomas B. Nutman
Journal:  Curr Infect Dis Rep       Date:  2002-02       Impact factor: 3.725

2.  Brugia malayi: comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model.

Authors:  Sivasakthivel Thirugnanam; Pandurangan Pandiaraja; Kalyanasundaram Ramaswamy; Vadivel Murugan; Munirathinam Gnanasekar; Krithika Nandakumar; Maryada Venkata Rami Reddy; Perumal Kaliraj
Journal:  Exp Parasitol       Date:  2007-03-06       Impact factor: 2.011

Review 3.  A comprehensive, model-based review of vaccine and repeat infection trials for filariasis.

Authors:  C Paul Morris; Holly Evans; Sasha E Larsen; Edward Mitre
Journal:  Clin Microbiol Rev       Date:  2013-07       Impact factor: 26.132

4.  Heightened measures of immune complex and complement function and immune complex-mediated granulocyte activation in human lymphatic filariasis.

Authors:  Prakash Senbagavalli; Rajamanickam Anuradha; Vadakkuppattu D Ramanathan; Vasanthapuram Kumaraswami; Thomas B Nutman; Subash Babu
Journal:  Am J Trop Med Hyg       Date:  2011-07       Impact factor: 2.345

Review 5.  Immunopathology of Dirofilaria immitis infection.

Authors:  F Simón; L H Kramer; A Román; W Blasini; R Morchón; C Marcos-Atxutegi; G Grandi; C Genchi
Journal:  Vet Res Commun       Date:  2006-12-23       Impact factor: 2.459

Review 6.  Dendritic cells and parasites: from recognition and activation to immune response instruction.

Authors:  Claudia Cristina Motran; Laura Fernanda Ambrosio; Ximena Volpini; Daiana Pamela Celias; Laura Cervi
Journal:  Semin Immunopathol       Date:  2016-09-01       Impact factor: 9.623

7.  B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection.

Authors:  C Martin; M Saeftel; P N Vuong; S Babayan; K Fischer; O Bain; A Hoerauf
Journal:  Infect Immun       Date:  2001-11       Impact factor: 3.441

8.  Interleukin-4 is essential for the control of microfilariae in murine infection with the filaria Litomosoides sigmodontis.

Authors:  L Volkmann; M Saeftel; O Bain; K Fischer; B Fleischer; A Hoerauf
Journal:  Infect Immun       Date:  2001-05       Impact factor: 3.441

9.  Multivalent fusion protein vaccine for lymphatic filariasis.

Authors:  Gajalakshmi Dakshinamoorthy; Abhilash Kumble Samykutty; Gnanasekar Munirathinam; Maryada Venkatarami Reddy; Ramaswamy Kalyanasundaram
Journal:  Vaccine       Date:  2012-10-02       Impact factor: 3.641

10.  Evaluating the efficacy of rBmHATαc as a multivalent vaccine against lymphatic filariasis in experimental animals and optimizing the adjuvant formulation.

Authors:  Gajalakshmi Dakshinamoorthy; Ramaswamy Kalyanasundaram
Journal:  Vaccine       Date:  2013-11-06       Impact factor: 3.641
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