Literature DB >> 10769000

Bactericidal/permeability-increasing protein prevents mucosal damage in an experimental rat model of chronic otitis media with effusion.

M J Nell1, H K Koerten, J J Grote.   

Abstract

In this study, the efficacy of bactericidal/permeability-increasing protein (BPI) was assessed in a rat model of chronic otitis media with effusion. BPI injection prevented disturbance of the mucociliary clearance system of the middle ear. Hence, it is postulated that BPI can be a new therapy for chronic otitis media with effusion.

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Year:  2000        PMID： 10769000      PMCID： PMC97515          DOI： 10.1128/IAI.68.5.2992-2994.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  15 in total

Review 1.  Otitis media update: pathogenesis and treatment.

Authors:  G S Giebink
Journal:  Ann Otol Rhinol Laryngol Suppl       Date:  1992-01

2.  Sem studies of the inflammatory changes of the middle ear mucosa.

Authors:  R Shimooka; K Yajin; Y Harada
Journal:  Auris Nasus Larynx       Date:  1983       Impact factor: 1.863

3.  Structural changes in the rat middle ear mucosa due to endotoxin and eustachian tube obstruction.

Authors:  M J Nell; J J Grote
Journal:  Eur Arch Otorhinolaryngol       Date:  1999       Impact factor: 2.503

4.  Endotoxin and tumor necrosis factor-alpha in middle ear effusions in relation to upper airway infection.

Authors:  M J Nell; J J Grote
Journal:  Laryngoscope       Date:  1999-11       Impact factor: 3.325

5.  Endotoxin in middle-ear effusions from patients with chronic otitis media with effusion.

Authors:  T F DeMaria; R B Prior; B R Briggs; D J Lim; H G Birck
Journal:  J Clin Microbiol       Date:  1984-07       Impact factor: 5.948

Review 6.  The bactericidal/permeability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopolysaccharide.

Authors:  P Elsbach; J Weiss
Journal:  Immunobiology       Date:  1993-04       Impact factor: 3.144

7.  Experimental otitis media with effusion following middle ear inoculation of nonviable H influenzae.

Authors:  T F DeMaria; B R Briggs; D J Lim; N Okazaki
Journal:  Ann Otol Rhinol Laryngol       Date:  1984 Jan-Feb       Impact factor: 1.547

8.  Loss of ciliary activity in organ cultures of rat trachea treated with lipo-oligosaccharide from Haemophilus influenzae.

Authors:  A P Johnson; T J Inzana
Journal:  J Med Microbiol       Date:  1986-11       Impact factor: 2.472

9.  Otitis media with effusion following inoculation of Haemophilus influenzae type b endotoxin.

Authors:  N Nonomura; Y Nakano; Y Satoh; O Fujioka; H Niijima; M Fujita
Journal:  Arch Otorhinolaryngol       Date:  1986

10.  Ten-year review of otitis media pathogens.

Authors:  C D Bluestone; J S Stephenson; L M Martin
Journal:  Pediatr Infect Dis J       Date:  1992-08       Impact factor: 2.129
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