UNLABELLED: The purpose of this study was to develop and evaluate a system for the continuous on-line measurement of expired 11CO2 during 11C PET studies. METHODS: A detector system was developed that allowed continuous sampling of expired air during PET. Healthy volunteers (n = 4) underwent PET with [11C]CO2 during which expired air, tomographic tissue activity, and blood data were collected. The measured expired-air 11CO2 radioactivity time courses were filtered, and an envelope was extracted and compared with the time course of 11CO2/H11CO3 in blood. RESULTS: Good agreement was found between the shapes of the expired-air envelope and the time course in blood, enabling quantitative calibration against discrete blood samples. CONCLUSION: A system for the continuous monitoring of expired radioactivity during PET has been developed and evaluated with [11C]CO2. This monitoring enables the quantitative continuous measurement of 11CO2/H11CO3- in blood.
UNLABELLED: The purpose of this study was to develop and evaluate a system for the continuous on-line measurement of expired 11CO2 during 11C PET studies. METHODS: A detector system was developed that allowed continuous sampling of expired air during PET. Healthy volunteers (n = 4) underwent PET with [11C]CO2 during which expired air, tomographic tissue activity, and blood data were collected. The measured expired-air 11CO2 radioactivity time courses were filtered, and an envelope was extracted and compared with the time course of 11CO2/H11CO3 in blood. RESULTS: Good agreement was found between the shapes of the expired-air envelope and the time course in blood, enabling quantitative calibration against discrete blood samples. CONCLUSION: A system for the continuous monitoring of expired radioactivity during PET has been developed and evaluated with [11C]CO2. This monitoring enables the quantitative continuous measurement of 11CO2/H11CO3- in blood.
Authors: David R Sprague; Masahiro Fujita; Yong Hoon Ryu; Jeih-San Liow; Victor W Pike; Robert B Innis Journal: Nucl Med Biol Date: 2008-05 Impact factor: 2.408
Authors: Marilyn P Law; Stefan Wagner; Klaus Kopka; Victor W Pike; Otmar Schober; Michael Schäfers Journal: Eur J Nucl Med Mol Imaging Date: 2007-09-29 Impact factor: 9.236