| Literature DB >> 10768201 |
K Nakayama1, H C Kawato, H Inagaki, R Nakajima, A Kitamura, K Someya, T Ohta.
Abstract
Structure-activity relationships of the west amino acid modified analogues of rhodopeptins, novel antifungal tetrapeptide isolated from Rhodococcus species Mer-N1033, have been investigated. Among the analogues synthesized, 2,2-difluoro and 2-hydroxy derivatives retained the antifungal activity with better physical properties, i.e., solubility or acute toxicity.Entities:
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Year: 2000 PMID： 10768201 DOI： 10.1021/ol005630k
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005