Literature DB >> 10767571

Membrane penetration enhancement of ibuprofen using supersaturation.

M Iervolino1, S L Raghavan, J Hadgraft.   

Abstract

Permeation enhancement of ibuprofen from supersaturated solutions formed using the cosolvent technique was investigated using silicone as a model membrane. Hydroxpropyl methyl cellulose and hydroxpropyl-beta-cyclodextrin were used to stabilise the supersaturated states. Physical stability studies showed best results for low drug concentrations in a 40:60 propylene glycol/water cosolvent system. Variations in flux across model silicone membranes from saturated solutions were observed as the PG content was increased. The flux of IBU increased with the degree of saturation for solutions prepared in a 40:60 PG/water cosolvent mixture. HPMC and CD were found to be effective in enhancing the stability of supersaturated solutions of IBU. The mechanisms of action are different for the two additives and are discussed.

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Year:  2000        PMID： 10767571     DOI： 10.1016/s0378-5173(00)00346-x

Source DB:  PubMed          Journal:  Int J Pharm        ISSN： 0378-5173            Impact factor:   5.875


  12 in total

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4.  Assessment of the lateral diffusion and penetration of topically applied drugs in humans using a novel concentric tape stripping design.

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Review 5.  Current Status of Supersaturable Self-Emulsifying Drug Delivery Systems.

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6.  Effect of adhesive layer thickness and drug loading on estradiol crystallization in a transdermal drug delivery system.

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Journal:  AAPS PharmSciTech       Date:  2010-08-13       Impact factor: 3.246

7.  Diclofenac-beta-cyclodextrin binary systems: physicochemical characterization and in vitro dissolution and diffusion studies.

Authors:  Maria Letizia Manca; Marco Zaru; Guido Ennas; Donatella Valenti; Chiara Sinico; Giuseppe Loy; Anna Maria Fadda
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8.  A comparative study of the in vitro permeation characteristic of sulphadiazine across synthetic membranes and eschar tissue.

Authors:  Behzad Sharif Makhmal Zadeh; Hamidreza Moghimi; Paulo Santos; Jonathan Hadgraft; Majella E Lane
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9.  In vitro permeation and in vivo anti-inflammatory and analgesic properties of nanoscaled emulsions containing ibuprofen for topical delivery.

Authors:  Ghassan Z Abdullah; Muthanna F Abdulkarim; Ibrahim M Salman; Omar Z Ameer; Mun F Yam; Ahmed F Mutee; Mallikarjun Chitneni; Elrashid S Mahdi; Mahiran Basri; Munavvar A Sattar; Azmin M Noor
Journal:  Int J Nanomedicine       Date:  2011-02-17

10.  Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system.

Authors:  Zhi-Qiang Chen; Ying Liu; Ji-Hui Zhao; Lan Wang; Nian-Ping Feng
Journal:  Int J Nanomedicine       Date:  2012-02-23
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