| Literature DB >> 10766293 |
C Cole1, A J Foster, S Freeman, M Jaffar, P E Murray, I J Strafford.
Abstract
The angiogenic growth factor thymidine phosphorylase/PD-ECGF has been identified as a potential target in the development of anti-cancer drugs. This review firstly discusses the biological rôle of TP/PD-ECGF and its importance in the activation of 5-fluorouracil and its prodrugs. The chemistry and chemotherapeutic potential of TP/PD-ECGF inhibitors are also discussed.Entities:
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Year: 1999 PMID： 10766293
Source DB: PubMed Journal: Anticancer Drug Des ISSN： 0266-9536