R Jorde1, J Sundsfjord. 1. Departments of Internal Medicine and Clinical Chemistry, University Hospital of Tromso, Tromso, Norway. medrj@rito.no
Abstract
OBJECTIVE: To evaluate bone mineral density and blood pressure in asymptomatic hyperparathyroidism. DESIGN: A case-control study. SETTING: The participants obtained from an epidemiological survey in Tromso 1994-95, that included more than 27 000 subjects. The re-examination in 1998 was performed at the University Hospital of Tromso, Norway. Participants. Thirty-nine subjects with hyperparathyroidism and 72 control subjects were studied. MAIN OUTCOME MEASURES: Bone mineral density measurements of the lumbar spine and the proximal femur (femoral neck, Ward's triangle, and trochanter). Systolic and diastolic blood pressure. RESULTS: In the hyperparathyroidism group bone mineral density was significantly lower measured at the lumbar spine (1.000 +/- 0.181 vs. 1.079 +/- 0. 194 g cm-2, mean +/- SD, P < 0.01) and at the femoral neck (0.806 +/- 0.121 vs. 0.852 +/- 0.141 g cm-2, P < 0.05). In the females, but not in the males, blood pressure was significantly higher in the hyperparathyroidism group than in the control group [systolic blood pressure 146.7 +/- 18.6 vs. 137.4 +/- 23.0 mmHg (P < 0.05) and diastolic blood pressure 88.1 +/- 11.8 vs. 82.2 +/- 10.6 mmHg (P < 0. 05)]. In the females the number of subjects on antihypertensive medication was significantly higher in the hyperparathyroidism group than in the control group (32.1% and 16.6%, respectively, P < 0.01). CONCLUSIONS: Subjects with asymptomatic hyperparathyroidism have moderately reduced bone mineral density. In females with hyperparathyroidism there is an increase in blood pressure.
OBJECTIVE: To evaluate bone mineral density and blood pressure in asymptomatic hyperparathyroidism. DESIGN: A case-control study. SETTING: The participants obtained from an epidemiological survey in Tromso 1994-95, that included more than 27 000 subjects. The re-examination in 1998 was performed at the University Hospital of Tromso, Norway. Participants. Thirty-nine subjects with hyperparathyroidism and 72 control subjects were studied. MAIN OUTCOME MEASURES: Bone mineral density measurements of the lumbar spine and the proximal femur (femoral neck, Ward's triangle, and trochanter). Systolic and diastolic blood pressure. RESULTS: In the hyperparathyroidism group bone mineral density was significantly lower measured at the lumbar spine (1.000 +/- 0.181 vs. 1.079 +/- 0. 194 g cm-2, mean +/- SD, P < 0.01) and at the femoral neck (0.806 +/- 0.121 vs. 0.852 +/- 0.141 g cm-2, P < 0.05). In the females, but not in the males, blood pressure was significantly higher in the hyperparathyroidism group than in the control group [systolic blood pressure 146.7 +/- 18.6 vs. 137.4 +/- 23.0 mmHg (P < 0.05) and diastolic blood pressure 88.1 +/- 11.8 vs. 82.2 +/- 10.6 mmHg (P < 0. 05)]. In the females the number of subjects on antihypertensive medication was significantly higher in the hyperparathyroidism group than in the control group (32.1% and 16.6%, respectively, P < 0.01). CONCLUSIONS: Subjects with asymptomatic hyperparathyroidism have moderately reduced bone mineral density. In females with hyperparathyroidism there is an increase in blood pressure.