Literature DB >> 10762051

Carbonic anhydrase inhibitors: topical sulfonamide antiglaucoma agents incorporating secondary amine moieties.

G Renzi1, A Scozzafava, C T Supuran.   

Abstract

Reaction of aromatic/heterocyclic sulfonamides possessing free amino, imino or hydrazino moieties with 7-chloro-4-chloromethylcoumarin afforded a series of N-[(7-chloro-4-coumarinyl)-methyl]- derivatives which showed effective inhibition of three carbonic anhydrase (CA) isozymes. Topical application within the rabbit eye of some of these compounds led to effective intraocular pressure lowering due to CA inhibition within the ocular tissues, and reduced aqueous humor production.

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Year:  2000        PMID： 10762051     DOI： 10.1016/s0960-894x(00)00075-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

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Journal:  Int J Mol Sci       Date:  2019-11-08       Impact factor: 5.923

7.  Design, synthesis and biological evaluation of carbohydrate-based sulphonamide derivatives as topical antiglaucoma agents through selective inhibition of carbonic anhydrase II.

Authors:  Zhuang Hou; Chuanchao Li; Yichuang Liu; Miao Zhang; Yitong Wang; Zhanfang Fan; Chun Guo; Bin Lin; Yang Liu
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  7 in total

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