| Literature DB >> 10762040 |
W Zheng1, L Lei, S Lalchandani, G Sun, D R Feller, D D Miller.
Abstract
A series of yohimbine dimers was prepared and evaluated at the human alpha2a- and alpha2b-adrenergic receptors (ARs) expressed in Chinese hamster ovary (CHO) cells. All dimers display higher binding selectivities for alpha2a versus alpha2b subtype than yohimbine, and four compounds (3d, 3e, 3g and 3i) represent the most potent and alpha2a versus alpha2b-AR selective ligands identified so far.Entities:
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Year: 2000 PMID： 10762040 DOI： 10.1016/s0960-894x(00)00068-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823