| Literature DB >> 10762038 |
K Kikuchi1, S Hibi, H Yoshimura, K Tai, T Hida, N Tokuhara, T Yamauchi, M Nagai.
Abstract
We have designed and synthesized a series of pyrazole derivatives as candidate retinoic acid receptor (RAR) agonists. One of them, 4-[5-(1, 5-diisopropyl-1H-3-pyrazolyl)-1H-2-pyrrolyl]benzoic acid (11b), which possesses a 2,5-disubstituted pyrrole moiety, showed selective transactivation activity for the RAR alpha receptor, and had highly potent cell-differentiating activity on HL-60 cells.Entities:
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Year: 2000 PMID： 10762038 DOI： 10.1016/s0960-894x(00)00066-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823