Literature DB >> 10761986

IDPN-induced monoamine and hydroxyl radical changes in the rat brain.

N Wakata1, Y Araki, H Sugimoto, H Iguchi, M Kinoshita.   

Abstract

beta-beta'-iminodipropionitrile (IDPN)-induced monoamine and hydroxyl radical changes in the rat brains were studied. IDPN caused decreases in 5-HT and 5-HIAA levels in all brain regions, strongly indicating that IDPN's neurotoxicity primarily affects 5-HT containing neurons. Dopamine and its metabolites' levels decreased in the some regions, most likely due to depression of dopamine metabolic turnover. Our results more clearly demonstrate IDPN-induced monoamine alterations in the rat brain more than previous reports. To clarify one of the pathogenesis of IDPN-induced neurological disorders, we measured hydroxyl radical levels. 2,3-DHBA increased at 1st day, and decreased in some regions at 7th days after discontinuing IDPN. We conclude, hydroxyl radical formation causes neuronal damage, and monoamine changes contribute to IDPN-induced neurological disorder.

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Year:  2000        PMID： 10761986     DOI： 10.1023/a:1007553323461

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  18 in total

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  5 in total

1.  Bupivacaine hydrochloride induces muscle fiber necrosis and hydroxyl radical formation-dimethyl sulphoxide reduces hydroxyl radical formation.

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Journal:  Neurochem Res       Date:  2001-07       Impact factor: 3.996

2.  Dual ameliorative effects of Ningdong granule on dopamine in rat models of Tourette's syndrome.

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3.  Time-Course Evaluation of Iminodipropionitrile-Induced Liver and Kidney Toxicities in Rats: A Biochemical, Molecular and Histopathological Study.

Authors:  Manar A Alwelaie; Mohsen G Al-Mutary; Nikhat J Siddiqi; Maha M Arafah; Abdullah S Alhomida; Haseeb A Khan
Journal:  Dose Response       Date:  2019-05-23       Impact factor: 2.658

4.  Neuroinflammation in a Rat Model of Tourette Syndrome.

Authors:  Ke Zhongling; Chen Yanhui; Chen Guofeng; Liu Yanyan
Journal:  Front Behav Neurosci       Date:  2022-03-10       Impact factor: 3.558

5.  Evidence for a Role of Orexin/Hypocretin System in Vestibular Lesion-Induced Locomotor Abnormalities in Rats.

Authors:  Leilei Pan; Ruirui Qi; Junqin Wang; Wei Zhou; Jiluo Liu; Yiling Cai
Journal:  Front Neurosci       Date:  2016-07-26       Impact factor: 4.677
  5 in total

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