Literature DB >> 10761859

Igf2 imprinting in development and disease.

W Reik1, M Constancia, W Dean, K Davies, L Bowden, A Murrell, R Feil, J Walter, G Kelsey.   

Abstract

Igf2 is one of the first imprinted genes discovered and occupies a centre stage in the study of imprinting. This is because it has dramatic effects on the control of fetal growth, it is involved in growth disorders and in cancer, it interacts with products of other imprinted genes, and its imprinting status is under complex regulation in a cluster of tightly linked imprinted genes. Here we review briefly the key features of Igf2 imprinting in normal development and in disease, and hope to show what a fascinating subject of study this gene and its biology provides.

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Year:  2000        PMID： 10761859

Source DB:  PubMed          Journal:  Int J Dev Biol        ISSN： 0214-6282            Impact factor:   2.203


  33 in total

1.  Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation.

Authors:  A A Wylie; S K Murphy; T C Orton; R L Jirtle
Journal:  Genome Res       Date:  2000-11       Impact factor: 9.043

2.  Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF.

Authors:  E M Klenova; I V Chernukhin; A El-Kady; R E Lee; E M Pugacheva; D I Loukinov; G H Goodwin; D Delgado; G N Filippova; J León; H C Morse; P E Neiman; V V Lobanenkov
Journal:  Mol Cell Biol       Date:  2001-03       Impact factor: 4.272

3.  Targeted tumor gene therapy based on loss of IGF2 imprinting.

Authors:  Yuqin Pan; Bangshun He; Tao Li; Chan Zhu; Lirong Zhang; Bo Wang; Yongfei Xu; Lili Qu; Andrew R Hoffman; Shukui Wang; Jifan Hu
Journal:  Cancer Biol Ther       Date:  2010-08-21       Impact factor: 4.742

4.  Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals.

Authors:  Aniek C Bouwman; Hans D Daetwyler; Amanda J Chamberlain; Carla Hurtado Ponce; Mehdi Sargolzaei; Flavio S Schenkel; Goutam Sahana; Armelle Govignon-Gion; Simon Boitard; Marlies Dolezal; Hubert Pausch; Rasmus F Brøndum; Phil J Bowman; Bo Thomsen; Bernt Guldbrandtsen; Mogens S Lund; Bertrand Servin; Dorian J Garrick; James Reecy; Johanna Vilkki; Alessandro Bagnato; Min Wang; Jesse L Hoff; Robert D Schnabel; Jeremy F Taylor; Anna A E Vinkhuyzen; Frank Panitz; Christian Bendixen; Lars-Erik Holm; Birgit Gredler; Chris Hozé; Mekki Boussaha; Marie-Pierre Sanchez; Dominique Rocha; Aurelien Capitan; Thierry Tribout; Anne Barbat; Pascal Croiseau; Cord Drögemüller; Vidhya Jagannathan; Christy Vander Jagt; John J Crowley; Anna Bieber; Deirdre C Purfield; Donagh P Berry; Reiner Emmerling; Kay-Uwe Götz; Mirjam Frischknecht; Ingolf Russ; Johann Sölkner; Curtis P Van Tassell; Ruedi Fries; Paul Stothard; Roel F Veerkamp; Didier Boichard; Mike E Goddard; Ben J Hayes
Journal:  Nat Genet       Date:  2018-02-19       Impact factor: 38.330

5.  Regulatory mechanisms at the mouse Igf2/H19 locus.

Authors:  C R Kaffer; A Grinberg; K Pfeifer
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

6.  Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis.

Authors:  Matthew R Ritter; Michael I Dorrell; Joseph Edmonds; Sheila Fallon Friedlander; Martin Friedlander
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

7.  Analysis of H19 methylation in control and abnormal human embryos, sperm and oocytes.

Authors:  Samira Ibala-Romdhane; Mohamed Al-Khtib; Rita Khoueiry; Thierry Blachère; Jean-François Guérin; Annick Lefèvre
Journal:  Eur J Hum Genet       Date:  2011-06-08       Impact factor: 4.246

8.  CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop.

Authors:  Tao Li; Ji-Fan Hu; Xinwen Qiu; Jianqun Ling; Huiling Chen; Shukui Wang; Aiju Hou; Thanh H Vu; Andrew R Hoffman
Journal:  Mol Cell Biol       Date:  2008-07-28       Impact factor: 4.272

9.  Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines.

Authors:  Tao Li; Huiling Chen; Wei Li; Jiuwei Cui; Guanjun Wang; Xiang Hu; Andrew R Hoffman; Jifan Hu
Journal:  Hum Mol Genet       Date:  2013-08-19       Impact factor: 6.150

10.  Loss of imprinting of insulin-like growth factor 2 is associated with increased risk of lymph node metastasis and gastric corpus cancer.

Authors:  Yang Lu; Ping Lu; Zhi Zhu; Huimian Xu; Xike Zhu
Journal:  J Exp Clin Cancer Res       Date:  2009-09-09
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