Phospholipid transfer proteins and physiological functions.

Issues of how cells generate and maintain unique lipid compositions in distinct intracellular membrane systems remain the subject of much study. A ubiquitous class of soluble proteins capable of transporting phospholipid monomers from membrane to membrane across an aqueous milieu has been thought to define part of the mechanism by which lipids are sorted in cells. Progress in the study of these phospholipid transfer proteins (PLTPs) raises questions regarding their physiological functions in cells and the mechanisms by which these proteins execute them. It is now clear that across the eukaryotic kingdom, members of this protein family exert essential roles in the regulation of phospholipid metabolism and central aspects of phospholipid-mediated signaling. Indeed, it is now known that dysfunction of specific PLTPs defines the basis of inherited diseases in mammals, and this list is expected to grow. Phospholipid transfer proteins, their biochemical properties, and the emerging clues regarding their physiological functions are reviewed.