Literature DB >> 10760598

Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3.

S Matsuda1, K Miyazaki, Y Ichigotani, H Kurata, Y Takenouchi, T Yamamoto, Y Nimura, T Irimura, S Nakatsugawa, M Hamaguchi.   

Abstract

A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library. This cDNA consists of 1990 bp and has a predicted open reading frame encoding 433 amino acids. It possesses an Src homology 3 (SH3) motif, a leucine zipper motif and no catalytic domain, suggesting that it seems to be an adapter protein. PCR-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 1q21-22.

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Year:  2000        PMID: 10760598     DOI: 10.1016/s0167-4781(00)00049-x

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  4 in total

1.  Crystal structure and functional implication of the RUN domain of human NESCA.

Authors:  Qifan Sun; Chuanhui Han; Lan Liu; Yizhi Wang; Hongyu Deng; Lin Bai; Tao Jiang
Journal:  Protein Cell       Date:  2012-07-22       Impact factor: 14.870

2.  The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization.

Authors:  Rie Sakamoto; Dana T Byrd; Heather M Brown; Naoki Hisamoto; Kunihiro Matsumoto; Yishi Jin
Journal:  Mol Biol Cell       Date:  2004-11-24       Impact factor: 4.138

3.  Identification and characterization of Iporin as a novel interaction partner for rab1.

Authors:  Michael Bayer; Julia Fischer; Joachim Kremerskothen; Edith Ossendorf; Theodoros Matanis; Magdalena Konczal; Thomas Weide; Angelika Barnekow
Journal:  BMC Cell Biol       Date:  2005-03-29       Impact factor: 4.241

4.  Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth.

Authors:  James I S MacDonald; Chris J Kubu; Susan O Meakin
Journal:  J Cell Biol       Date:  2004-03-15       Impact factor: 10.539

  4 in total

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