Literature DB >> 10760035

Hepatitis C virus (HCV) NS5A protein: role in HCV replication and resistance to interferon-alpha.

J M Pawlotsky1.   

Abstract

The hepatitis C virus (HCV) non-structural (NS) 5A protein appears to play an important regulatory role on viral replication and could also be involved in viral pathogenesis. HCV resistance to interferon is a complex mechanism involving multiple causes, among which certain NS5A functions could play a role.

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Year:  1999        PMID： 10760035     DOI： 10.1046/j.1365-2893.1999.00004.x

Source DB:  PubMed          Journal:  J Viral Hepat        ISSN： 1352-0504            Impact factor:   3.728


  5 in total

1.  The mode and tempo of hepatitis C virus evolution within and among hosts.

Authors:  Rebecca R Gray; Joe Parker; Philippe Lemey; Marco Salemi; Aris Katzourakis; Oliver G Pybus
Journal:  BMC Evol Biol       Date:  2011-05-19       Impact factor: 3.260

2.  Cloning and identification of NS5ATP2 gene and its spliced variant transactivated by hepatitis C virus non-structural protein 5A.

Authors:  Qian Yang; Jun Cheng; Yan Liu; Yuan Hong; Jian-Jun Wang; Shu-Lin Zhang
Journal:  World J Gastroenterol       Date:  2004-06-15       Impact factor: 5.742

3.  Prediction of prognostic biomarkers for interferon-based therapy to hepatitis C virus patients: a meta-analysis of the NS5A protein in subtypes 1a, 1b, and 3a.

Authors:  Mahmoud M ElHefnawi; Suher Zada; Iman A El-Azab
Journal:  Virol J       Date:  2010-06-15       Impact factor: 4.099

4.  A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication.

Authors:  Ella H Sklan; Kirk Staschke; Tina M Oakes; Menashe Elazar; Mark Winters; Benjamin Aroeti; Tsafi Danieli; Jeffrey S Glenn
Journal:  J Virol       Date:  2007-08-08       Impact factor: 5.103

5.  Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles.

Authors:  Takahiro Masaki; Ryosuke Suzuki; Kyoko Murakami; Hideki Aizaki; Koji Ishii; Asako Murayama; Tomoko Date; Yoshiharu Matsuura; Tatsuo Miyamura; Takaji Wakita; Tetsuro Suzuki
Journal:  J Virol       Date:  2008-06-04       Impact factor: 5.103
  5 in total

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