S C Radley1, C R Chapple, J A Lee. 1. Departments of Urology and Pathology, Royal Hallamshire Hospital, Sheffield, UK.
Abstract
OBJECTIVE: To evaluate the anatomical location, histological appearances and mechanism of action of sili-cone polymer (Macroplastique(R)) after transurethral implantation. MATERIALS AND METHODS: An in vivo pig model was developed to investigate the organization of Macroplastique 6 weeks after injection. The results were compared with the immediate appearance of injected Macroplastique in a surgical training device (using isolated pig urethrae) and with the histological appearances of Macroplastique in an explanted human specimen. RESULTS: Macroplastique was subserosal in all specimens; it provoked a marked foreign-body inflammatory reaction, producing firm nodules 6 weeks after implantation. The histological appearances in the in vivo pig model and the human specimen were indistinguishable. CONCLUSIONS: These findings indicate that the mechanism of action of Macroplastique is to augment pressure transmission to the proximal urethra by producing focal but firm expansion of periurethral tissues.
OBJECTIVE: To evaluate the anatomical location, histological appearances and mechanism of action of sili-cone polymer (Macroplastique(R)) after transurethral implantation. MATERIALS AND METHODS: An in vivo pig model was developed to investigate the organization of Macroplastique 6 weeks after injection. The results were compared with the immediate appearance of injected Macroplastique in a surgical training device (using isolated pig urethrae) and with the histological appearances of Macroplastique in an explanted human specimen. RESULTS: Macroplastique was subserosal in all specimens; it provoked a marked foreign-body inflammatory reaction, producing firm nodules 6 weeks after implantation. The histological appearances in the in vivo pig model and the human specimen were indistinguishable. CONCLUSIONS: These findings indicate that the mechanism of action of Macroplastique is to augment pressure transmission to the proximal urethra by producing focal but firm expansion of periurethral tissues.
Authors: Philip van Kerrebroeck; Flip ter Meulen; Elisabeth Farrelly; Gregor Larsson; Lena Edwall; Aino Fianu-Jonasson Journal: Urol Res Date: 2003-01-30