Literature DB >> 10758406

CD14, new aspects of ligand and signal diversity.

R Landmann1, B Müller, W Zimmerli.   

Abstract

The glycosyl-phosphatidylinositol-linked glycoprotein CD14 is expressed in myeloid cells and serum. It binds Gram-negative and -positive bacterial cell wall components and endogenous phospholipids. Toll-like receptors, NF-kappaB and MAP kinases participate in CD14 signaling of inflammation. Alterations of CD14 in inflammatory diseases support a pathogenic role for this microbial receptor.

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Year:  2000        PMID： 10758406     DOI： 10.1016/s1286-4579(00)00298-7

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  35 in total

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