Literature DB >> 10756621

The newer, 'atypical' antipsychotic drugs--their development and current therapeutic use.

T Kendrick1.   

Abstract

General practitioners (GPs) need to become more aware of a new generation of antipsychotic drugs that are 'atypical' in that, unlike traditional neuroleptics, they do not cause extrapyramidal side-effects; they may also be more effective against both the positive and negative symptoms of schizophrenia by their actions on various neurotransmitter pathways in the brain. This is a non-systematic review of the development of these new drugs and outlines how they are currently being used. It includes information found from an electronic search of the databases MEDLINE (from 1966 to June 1998) and EMBASE (from 1980 to January 1998) using the combined search terms 'antipsychotic agents', 'atypical', and 'schizophrenia'.

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Year:  1999        PMID: 10756621      PMCID: PMC1313507     

Source DB:  PubMed          Journal:  Br J Gen Pract        ISSN: 0960-1643            Impact factor:   5.386


  43 in total

1.  Typical and atypical antipsychotic occupancy of D2 and S2 receptors: an autoradiographic analysis in rat brain.

Authors:  C A Altar; A M Wasley; R F Neale; G A Stone
Journal:  Brain Res Bull       Date:  1986-04       Impact factor: 4.077

2.  IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol.

Authors:  B Küfferle; J Tauscher; S Asenbaum; C Vesely; I Podreka; T Brücke; S Kasper
Journal:  Psychopharmacology (Berl)       Date:  1997-10       Impact factor: 4.530

3.  Dopamine and the pharmacology of schizophrenia: the state of the evidence.

Authors:  S Matthysse
Journal:  J Psychiatr Res       Date:  1974       Impact factor: 4.791

4.  Agranulocytosis in patients treated with clozapine. A study of the Finnish epidemic.

Authors:  H A Amsler; L Teerenhovi; E Barth; K Harjula; P Vuopio
Journal:  Acta Psychiatr Scand       Date:  1977-10       Impact factor: 6.392

5.  The risks and benefits of clozapine versus chlorpromazine.

Authors:  J Claghorn; G Honigfeld; F S Abuzzahab; R Wang; R Steinbook; V Tuason; G Klerman
Journal:  J Clin Psychopharmacol       Date:  1987-12       Impact factor: 3.153

6.  Regional blockade by neuroleptic drugs of in vivo 3H-spiperone binding in the rat brain. Relation to blockade of apomorphine induced hyperactivity and stereotypies.

Authors:  C Köhler; L Haglund; S O Ogren; T Angeby
Journal:  J Neural Transm       Date:  1981       Impact factor: 3.575

7.  Social skills training for patients with schizophrenia: a controlled clinical trial.

Authors:  C J Wallace; R P Liberman
Journal:  Psychiatry Res       Date:  1985-07       Impact factor: 3.222

8.  Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.

Authors:  P A Janssen; C J Niemegeers; F Awouters; K H Schellekens; A A Megens; T F Meert
Journal:  J Pharmacol Exp Ther       Date:  1988-02       Impact factor: 4.030

9.  The effect of long-term treatment with clozapine in schizophrenia: a retrospective study in 96 patients treated with clozapine for up to 13 years.

Authors:  L H Lindström
Journal:  Acta Psychiatr Scand       Date:  1988-05       Impact factor: 6.392

10.  Tolerability and therapeutic effect of clozapine. A retrospective investigation of 216 patients treated with clozapine for up to 12 years.

Authors:  U Juul Povlsen; U Noring; R Fog; J Gerlach
Journal:  Acta Psychiatr Scand       Date:  1985-02       Impact factor: 6.392

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