| Literature DB >> 10755628 |
K A Young, Y Akyon, D S Rampton1, S G R G Barton1, R P Allaker, J M Hardie, R A Feldman1.
Abstract
The transmission of Helicobacter pylori may occur by spread of organisms from gastric juice which has been introduced into the mouth by gastro-oesophageal reflux. The aim of this study was to quantify the load of H. pylori present in gastric juice available for transmission. Gastric antral biopsy and gastric juice samples were collected from 108 adult dyspeptic patients undergoing routine upper gastroscopy and the presence of H. pylori was determined. In all, 54 (50%) of 108 patients gave positive results in the gastric antral biopsy rapid urease test and for H. pylori histology. The gastric juice of 40 (37%) of patients gave positive results for the urease A gene by PCR assay; 34 (31%) of patients were positive by these three tests and H. pylori was cultured from the gastric juice of 13 (38%) of these patients. The median count of H. pylori in gastric juice was 1.75 x 10(1) cfu/ml. Viable organisms in gastric juice may lead to transmission of H. pylori when refluxed or vomited into the mouth.Entities:
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Year: 2000 PMID： 10755628 DOI： 10.1099/0022-1317-49-4-343
Source DB: PubMed Journal: J Med Microbiol ISSN： 0022-2615 Impact factor: 2.472