Literature DB >> 10754227

Expression of prostaglandin E synthase mRNA is induced in beta-amyloid treated rat astrocytes.

K Satoh1, Y Nagano, C Shimomura, N Suzuki, Y Saeki, H Yokota.   

Abstract

Deposition of beta-amyloid (A beta) in the brain is considered to be one of the most critical events in the onset of Alzheimer's disease (AD). In order to identify factors involved in the exacerbation of AD, we investigated transcriptionally A beta-induced genes using a cDNA subtraction technique in rat astrocytes. One gene obtained was rat prostaglandin (PG) E synthase. In this report, we present the deduced sequence for rat PGE synthase for the first time and demonstrate the induction of PGE synthase mRNA by treatment of cells with A beta. Our results suggest a possibly significant role of this enzyme in the progression of AD.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10754227     DOI： 10.1016/s0304-3940(00)00926-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  9 in total

1.  The three-dimensional map of microsomal glutathione transferase 1 at 6 A resolution.

Authors:  I Schmidt-Krey; K Mitsuoka; T Hirai; K Murata; Y Cheng; Y Fujiyoshi; R Morgenstern; H Hebert
Journal:  EMBO J       Date:  2000-12-01       Impact factor: 11.598

2.  Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes.

Authors:  Miriam Font-Nieves; M Glòria Sans-Fons; Roser Gorina; Ester Bonfill-Teixidor; Angélica Salas-Pérdomo; Leonardo Márquez-Kisinousky; Tomàs Santalucia; Anna M Planas
Journal:  J Biol Chem       Date:  2012-01-04       Impact factor: 5.157

Review 3.  Molecular Mechanisms of Metal Toxicity in the Pathogenesis of Alzheimer's Disease.

Authors:  Md Tanvir Kabir; Md Sahab Uddin; Sonia Zaman; Yesmin Begum; Ghulam Md Ashraf; May N Bin-Jumah; Simona G Bungau; Shaker A Mousa; Mohamed M Abdel-Daim
Journal:  Mol Neurobiol       Date:  2020-09-05       Impact factor: 5.590

4.  Shunting of prostanoid biosynthesis in microsomal prostaglandin E synthase-1 null embryo fibroblasts: regulatory effects on inducible nitric oxide synthase expression and nitrite synthesis.

Authors:  Mohit Kapoor; Fumiaki Kojima; Min Qian; Lihua Yang; Leslie J Crofford
Journal:  FASEB J       Date:  2006-10-03       Impact factor: 5.191

5.  Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett's metaplasia induced by duodenal contents reflux.

Authors:  T J Jang; S K Min; J D Bae; K H Jung; J I Lee; J R Kim; W S Ahn
Journal:  Gut       Date:  2004-01       Impact factor: 23.059

Review 6.  Prostaglandin E2 synthases in neurologic homeostasis and disease.

Authors:  M Kerry O'Banion
Journal:  Prostaglandins Other Lipid Mediat       Date:  2009-04-22       Impact factor: 3.072

7.  Expression of proteins related to prostaglandin E2 biosynthesis is increased in human gastric cancer and during gastric carcinogenesis.

Authors:  Tae Jung Jang
Journal:  Virchows Arch       Date:  2004-09-14       Impact factor: 4.064

8.  Cerebral arachidonate cascade in dementia: Alzheimer's disease and vascular dementia.

Authors:  Tatsurou Yagami
Journal:  Curr Neuropharmacol       Date:  2006-01       Impact factor: 7.363

9.  Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease.

Authors:  Uzma A Chaudhry; Hean Zhuang; Barbara J Crain; Sylvain Doré
Journal:  Alzheimers Dement       Date:  2007-12-21       Impact factor: 21.566
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.