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Cell polarity: fixing cell polarity with Pins.

Abstract

A protein complex is assembled in a step-wise manner at the apical pole of Drosophila neuroblasts. This complex organizes the apical-basal polarity of asymmetrically dividing neuroblasts, and may act via G-protein signalling.

Entities: Gene Species

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Year: 2000 PMID： 10753742 DOI： 10.1016/s0960-9822(00)00402-4

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

Cell polarity: fixing cell polarity with Pins.

1. MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cells.

2. Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells.