Literature DB >> 10753403

Round-Window Microcatheter-Administered Microdose Gentamicin: Results from Treatment of Tinnitus Associated with Menière's Disease.

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Abstract

In this study, we review the results of Menière's disease treatment using microdose gentamicin delivered directly to the round window using the Round Window Microcatheter (IntraEar, Inc., Denver, CO). A total of 18 patients were studied, with follow-up ranging from 6 to 18 months. In 15 of 18 patients (83%), tinnitus was improved significantly throughout the follow-up period. Vertigo was eliminated in all patients, and pressure was relieved in 17 of 18 (94%). Ihese preliminary data suggest that Round Window Microcatheter-delivered gentamicin is a safe and effective treatment for the reduction of tinnitus, vertigo, and pressure associated with Menière's disease.

Entities:  

Year:  1998        PMID: 10753403

Source DB:  PubMed          Journal:  Int Tinnitus J        ISSN: 0946-5448


  3 in total

1.  Distribution of gentamicin in the guinea pig inner ear after local or systemic application.

Authors:  Shun-Ichi Imamura; Joe C Adams
Journal:  J Assoc Res Otolaryngol       Date:  2003-06

Review 2.  Microsystems technologies for drug delivery to the inner ear.

Authors:  Erin E Leary Pararas; David A Borkholder; Jeffrey T Borenstein
Journal:  Adv Drug Deliv Rev       Date:  2012-02-21       Impact factor: 15.470

Review 3.  Is gentamycin delivery via sustained-release vehicles a safe and effective treatment for refractory Meniere's disease? A critical analysis of published interventional studies.

Authors:  Petros V Vlastarakos; Emily Iacovou; Thomas P Nikolopoulos
Journal:  Eur Arch Otorhinolaryngol       Date:  2016-09-13       Impact factor: 2.503

  3 in total

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