OBJECTIVE: Bone fractures are an important cause of morbidity and mortality among the elderly in the US. The present study assesses the possible role of a number of risk factors for postmenopausal bone fractures. METHODS: We analysed the relationships of anthropometric, demographic and lifestyle factors with the risk of bone fracture among 6250 postmenopausal women in a prospective cohort study, the New York University Women's Health Study. RESULTS: After an average of 7.6 years of follow-up, 1025 new incident bone fractures were reported, including 34 hip and 159 wrist fractures (incidence rates; 71.6 and 334.7 per 105 woman-years, respectively). The risk of fracture increased with increasing age, body height and total fat intake, while it was significantly lower among obese and African American women. The relative risk among African Americans was 0.45 (95% CI: 0.32-0.63) compared with non-African Americans. Women taller than 170 cm had a 64% increase in risk of fractures, as compared with those under 155 cm. These associations were generally more pronounced when fractures were limited to those at the hip and wrist. CONCLUSIONS: The present study provides an indication for a potential role of dietary fat in the development of postmenopausal fractures and further evidence to support protective effects of obesity, short stature and African American ethnicity.
OBJECTIVE:Bone fractures are an important cause of morbidity and mortality among the elderly in the US. The present study assesses the possible role of a number of risk factors for postmenopausal bone fractures. METHODS: We analysed the relationships of anthropometric, demographic and lifestyle factors with the risk of bone fracture among 6250 postmenopausal women in a prospective cohort study, the New York University Women's Health Study. RESULTS: After an average of 7.6 years of follow-up, 1025 new incident bone fractures were reported, including 34 hip and 159 wrist fractures (incidence rates; 71.6 and 334.7 per 105 woman-years, respectively). The risk of fracture increased with increasing age, body height and total fat intake, while it was significantly lower among obese and African American women. The relative risk among African Americans was 0.45 (95% CI: 0.32-0.63) compared with non-African Americans. Women taller than 170 cm had a 64% increase in risk of fractures, as compared with those under 155 cm. These associations were generally more pronounced when fractures were limited to those at the hip and wrist. CONCLUSIONS: The present study provides an indication for a potential role of dietary fat in the development of postmenopausal fractures and further evidence to support protective effects of obesity, short stature and African American ethnicity.
Authors: Donna L Thorpe; Synnove F Knutsen; W Lawrence Beeson; Sujatha Rajaram; Gary E Fraser Journal: Public Health Nutr Date: 2007-08-09 Impact factor: 4.022
Authors: Sherita Hill Golden; Arleen Brown; Jane A Cauley; Marshall H Chin; Tiffany L Gary-Webb; Catherine Kim; Julie Ann Sosa; Anne E Sumner; Blair Anton Journal: J Clin Endocrinol Metab Date: 2012-06-22 Impact factor: 5.958
Authors: Muhammad Nadeem Aslam; Ingrid Bergin; Karl Jepsen; Jaclynn M Kreider; Kristin H Graf; Madhav Naik; Steven A Goldstein; James Varani Journal: Biol Trace Elem Res Date: 2013-10-06 Impact factor: 3.738
Authors: Anne McTiernan; Jean Wactawski-Wende; LieLing Wu; Rebecca J Rodabough; Nelson B Watts; Frances Tylavsky; Ruth Freeman; Susan Hendrix; Rebecca Jackson Journal: Am J Clin Nutr Date: 2009-04-29 Impact factor: 7.045
Authors: Ellen B Fung; Paul R Harmatz; Meredith Milet; Thomas D Coates; Alexis A Thompson; Mark Ranalli; Robert Mignaca; Charles Scher; Patricia Giardina; Shanda Robertson; Lynne Neumayr; Elliott P Vichinsky Journal: Bone Date: 2008-03-15 Impact factor: 4.398