Literature DB >> 10745268

Prompt and durable engraftment in two older adult patients with high risk chronic myelogenous leukemia (CML) using ex vivo expanded and unmanipulated unrelated umbilical cord blood.

A L Pecora1, P Stiff, A Jennis, S Goldberg, R Rosenbluth, P Price, K L Goltry, J Douville, R D Armstrong, A K Smith, R A Preti.   

Abstract

Delayed engraftment, graft failure, and adverse transplant-related events have been observed in unrelated umbilical cord blood (UCB) recipients, particularly in those receiving a low leukocyte cell dose and in CML patients. We report the outcomes of two older adult patients with high risk CML who received a low leukocyte cell dose of unmanipulated UCB cells supplemented with ex vivo expanded (AastromReplicell System) UCB cells. Each engrafted promptly and neither patient experienced GVHD or life-threatening infection. Both remain engrafted with cells exclusively of donor origin and are in cytogenetic remission at 19 and 8 months follow-up. Ex vivo expanded UCB cells appear to facilitate hematopoietic recovery and therefore may increase the number of CML patients eligible for unrelated UCB transplant.

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Year:  2000        PMID： 10745268     DOI： 10.1038/sj.bmt.1702222

Source DB:  PubMed          Journal:  Bone Marrow Transplant        ISSN： 0268-3369            Impact factor:   5.483


  20 in total

1.  Combination of HOXB4 and Delta-1 ligand improves expansion of cord blood cells.

Authors:  Korashon L Watts; Colleen Delaney; R Keith Humphries; Irwin D Bernstein; Hans-Peter Kiem
Journal:  Blood       Date:  2010-10-04       Impact factor: 22.113

Review 2.  Cord blood stem cells for hematopoietic transplantation.

Authors:  Anfisa Stanevsky; Avichai Shimoni; Ronit Yerushalmi; Arnon Nagler
Journal:  Stem Cell Rev Rep       Date:  2011-06       Impact factor: 5.739

3.  In silico analyses of proteomic data suggest a role for heat shock proteins in umbilical cord blood hematopoietic stem cells.

Authors:  Angelo D'Alessandro; Giuliano Grazzini; Bruno Giardina; Lello Zolla
Journal:  Stem Cell Rev Rep       Date:  2010-12       Impact factor: 5.739

4.  CD34(+) expansion with Delta-1 and HOXB4 promotes rapid engraftment and transfusion independence in a Macaca nemestrina cord blood transplant model.

Authors:  Korashon L Watts; Colleen Delaney; Veronica Nelson; Grant D Trobridge; Brian C Beard; R Keith Humphries; Hans-Peter Kiem
Journal:  Mol Ther       Date:  2013-04-16       Impact factor: 11.454

Review 5.  Status of umbilical cord blood transplantation in the year 2001.

Authors:  J M Hows
Journal:  J Clin Pathol       Date:  2001-06       Impact factor: 3.411

Review 6.  Strategies to enhance umbilical cord blood stem cell engraftment in adult patients.

Authors:  Colleen Delaney; Mariusz Z Ratajczak; Mary J Laughlin
Journal:  Expert Rev Hematol       Date:  2010-06       Impact factor: 2.929

7.  Hematopoietic stem cell expansion facilitates multilineage engraftment in a nonhuman primate cord blood transplantation model.

Authors:  Korashon L Watts; Veronica Nelson; Brent L Wood; Grant D Trobridge; Brian C Beard; R Keith Humphries; Hans-Peter Kiem
Journal:  Exp Hematol       Date:  2011-12-08       Impact factor: 3.084

8.  Low rate of infusional toxicity after expanded cord blood transplantation.

Authors:  Adham S Bear; Patrick J Hanley; Doyle M Bosque; Conrad R Cruz; Indresh Kaur; Hao Liu; Partow Kebriaei; Chitra Hosing; Katayoun Rezvani; Betul Oran; Marcos J De Lima; Catherine M Bollard; Elizabeth J Shpall
Journal:  Cytotherapy       Date:  2014-02-28       Impact factor: 5.414

9.  Potential for a pluripotent adult stem cell treatment for acute radiation sickness.

Authors:  Denis O Rodgerson; Bruce E Reidenberg; Alan G Harris; Andrew L Pecora
Journal:  World J Exp Med       Date:  2012-06-20

10.  Umbilical cord blood transplantation.

Authors:  Hong Hoe Koo; Hyo Seop Ahn
Journal:  Korean J Pediatr       Date:  2012-07-17
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