Literature DB >> 10743960

Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives.

G Wells1, T D Bradshaw, P Diana, A Seaton, D F Shi, A D Westwell, M F Stevens.   

Abstract

The synthesis of a series of new antitumour agents, the benzothiazole substituted quinol ethers and esters, is reported via the hypervalent iodine mediated oxidation of hydroxylated 2-phenylbenzothiazoles. The products were found to be active in vitro against human colon and breast cancer cell lines with IC50 values in the nanomolar range.

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Year:  2000        PMID： 10743960     DOI： 10.1016/s0960-894x(00)00027-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Synthesis, Characterization, and Biological Evaluation of certain 6-methyl-2(3H)-benzo-1, 3-thiazolyl-1'-ethylidene-2-(o, p- Substituted Acetophenones) Hydrazine Analogs.

Authors:  G Alang; G Kaur; R Kaur; A Singh; R Tiwari
Journal:  J Young Pharm       Date:  2010-10

2.  Quinol derivatives as potential trypanocidal agents.

Authors:  Amy Capes; Stephen Patterson; Susan Wyllie; Irene Hallyburton; Iain T Collie; Andrew J McCarroll; Malcolm F G Stevens; Julie A Frearson; Paul G Wyatt; Alan H Fairlamb; Ian H Gilbert
Journal:  Bioorg Med Chem       Date:  2011-12-27       Impact factor: 3.641

3.  Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation.

Authors:  Damien Hédou; Carole Dubouilh-Benard; Nadège Loaëc; Laurent Meijer; Corinne Fruit; Thierry Besson
Journal:  Molecules       Date:  2016-06-18       Impact factor: 4.411

4.  Synthesis, crystal structure, Hirshfeld surface investigation and comparative DFT studies of ethyl 2-[2-(2-nitrobenzylidene)hydrazinyl]thiazole-4-carboxylate.

Authors:  Muhammad Haroon; Tashfeen Akhtar; Muhammad Yousuf; Muhammad Nawaz Tahir; Lubna Rasheed; Syeda Saniya Zahra; Ihsan Ul Haq; Muhammad Ashfaq
Journal:  BMC Chem       Date:  2022-03-22

5.  One-pot synthesis of 2'-aminobenzothiazolo-arylmethyl-2-naphthols catalyzed by NBS under solvent-free conditions.

Authors:  Wei Lin Li; Li Li Wang; Qiu Yan Luo
Journal:  ScientificWorldJournal       Date:  2013-05-30
  5 in total

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