| Literature DB >> 10743944 |
T F Walsh1, R B Toupence, J R Young, S X Huang, F Ujjainwalla, R J DeVita, M T Goulet, M J Wyvratt, M H Fisher, J L Lo, N Ren, J B Yudkovitz, Y T Yang, K Cheng, R G Smith.
Abstract
SAR studies which focused upon the C-6 position of a recently described series of quinolone gonadotropin releasing hormone antagonists are reported. Synthetic access to diverse quinolone-6-carboxamides was achieved via the palladium-catalyzed amino-carbonylation reactions of iodide 4 with various amines. Amides related to 9y were especially potent, functional antagonists of rat and human GnRH receptors.Entities:
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Year: 2000 PMID： 10743944 DOI： 10.1016/s0960-894x(00)00024-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823