Literature DB >> 10743942

Design and synthesis of mimics of S-adenosyl-L-homocysteine as potential inhibitors of erythromycin methyltransferases.

S Hanessian1, P W Sgarbi.   

Abstract

A series of indanotriazine C-ribosides were prepared as SAH mimics, and tested for their ability to inhibit erythromycin resistance methylases Erm AM and Erm C'. A carbocyclic analogue derived from quinic acid was also synthesized and tested.

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Year:  2000        PMID： 10743942     DOI： 10.1016/s0960-894x(00)00021-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Structural and functional characterization of CFE88: evidence that a conserved and essential bacterial protein is a methyltransferase.

Authors:  Keith L Constantine; Stanley R Krystek; Matthew D Healy; Michael L Doyle; Nathan O Siemers; Jane Thanassi; Ning Yan; Dianlin Xie; Valentina Goldfarb; Joseph Yanchunas; Li Tao; Brian A Dougherty; Bennett T Farmer
Journal:  Protein Sci       Date:  2005-06       Impact factor: 6.725

2.  Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens.

Authors:  Kylie A Farrow; Dena Lyras; Galina Polekhina; Katerina Koutsis; Michael W Parker; Julian I Rood
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

3.  Microwave-assisted efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines.

Authors:  Moustafa Sherief Moustafa; Ramadan Ahmed Mekheimer; Saleh Mohammed Al-Mousawi; Mohamed Abd-Elmonem; Hesham El-Zorba; Afaf Mohamed Abdel Hameed; Tahany Mahmoud Mohamed; Kamal Usef Sadek
Journal:  Beilstein J Org Chem       Date:  2020-07-16       Impact factor: 2.883
  3 in total

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