Literature DB >> 10743939

Synthesis and biological activities of NB-506 analogues modified at the glucose group.

M Ohkubo1, T Nishimura, H Kawamoto, M Nakano, T Honma, T Yoshinari, H Arakawa, H Suda, H Morishima, S Nishimura.   

Abstract

A new indolocarbazole compound, NB-506 (1), modified at the glucose group yielded a beta-D-glucopyranoside, J-107,088 (2), which showed potent anticancer activity. A beta-D-ribofuranoside, J-109,534 (3), was found to be 6 times more potent than J-107,088 at inhibiting topoisomerase I.

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Year:  2000        PMID： 10743939     DOI： 10.1016/s0960-894x(00)00004-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity.

Authors:  Katherine E Peterson; Maris A Cinelli; Andrew E Morrell; Akhil Mehta; Thomas S Dexheimer; Keli Agama; Smitha Antony; Yves Pommier; Mark Cushman
Journal:  J Med Chem       Date:  2011-06-28       Impact factor: 7.446

2.  Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776).

Authors:  Daniel E Beck; Keli Agama; Christophe Marchand; Adel Chergui; Yves Pommier; Mark Cushman
Journal:  J Med Chem       Date:  2014-02-11       Impact factor: 7.446

3.  Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities.

Authors:  Yuet Wu; Silvia Parapini; Ian D Williams; Paola Misiano; Ho Ning Wong; Donatella Taramelli; Nicoletta Basilico; Richard K Haynes
Journal:  Molecules       Date:  2018-07-13       Impact factor: 4.411
  3 in total

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