OBJECTIVE: To examine if childhood psychiatric diagnoses are associated with family history, psychosis, age, and lithium response. METHOD: Associations among variables, and their contributions to explaining lithium response were examined in 48 bipolar adolescents enrolled in a study oflithium. RESULTS: Presence of a childhood diagnosis was not associated with family psychiatric history or lithium response. Subjects with psychotic features, however, were less likely to have a childhood psychiatric diagnosis, were older, and had a poorer response rate to lithium than subjects without psychosis. DISCUSSION: Heterogeneity within bipolar adolescents may be based on clinical features such as psychosis rather than childhood or family history alone.
RCT Entities:
OBJECTIVE: To examine if childhood psychiatric diagnoses are associated with family history, psychosis, age, and lithium response. METHOD: Associations among variables, and their contributions to explaining lithium response were examined in 48 bipolar adolescents enrolled in a study of lithium. RESULTS: Presence of a childhood diagnosis was not associated with family psychiatric history or lithium response. Subjects with psychotic features, however, were less likely to have a childhood psychiatric diagnosis, were older, and had a poorer response rate to lithium than subjects without psychosis. DISCUSSION: Heterogeneity within bipolar adolescents may be based on clinical features such as psychosis rather than childhood or family history alone.
Authors: Amy E West; Sally M Weinstein; Christine I Celio; David Henry; Mani N Pavuluri Journal: J Child Adolesc Psychopharmacol Date: 2011-12-02 Impact factor: 2.576
Authors: Christoph U Correll; Marta Hauser; Julie B Penzner; Andrea M Auther; Vivian Kafantaris; Ema Saito; Doreen Olvet; Ricardo E Carrión; Boris Birmaher; Kiki D Chang; Melissa P DelBello; Manpreet K Singh; Mani Pavuluri; Barbara A Cornblatt Journal: Bipolar Disord Date: 2014-03-05 Impact factor: 6.744