Literature DB >> 10741561

Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine.

R J Young1, R M Beams, K Carter, H A Clark, D M Coe, C L Chambers, P I Davies, J Dawson, M J Drysdale, K W Franzman, C French, S T Hodgson, H F Hodson, S Kleanthous, P Rider, D Sanders, D A Sawyer, K J Scott, B G Shearer, R Stocker, S Smith, M C Tackley, R G Knowles.   

Abstract

The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of human nitric oxide synthase enzymes, including examples with marked selectivity for the inducible isoform.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10741561     DOI： 10.1016/s0960-894x(00)00055-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

Review 1.  Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery.

Authors:  Candice E Paulsen; Kate S Carroll
Journal:  Chem Rev       Date:  2013-03-20       Impact factor: 60.622

Review 2.  Nitric oxide synthases: structure, function and inhibition.

Authors:  W K Alderton; C E Cooper; R G Knowles
Journal:  Biochem J       Date:  2001-08-01       Impact factor: 3.857

3.  GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.

Authors:  Wendy K Alderton; Anthony D R Angell; Caroline Craig; John Dawson; Edward Garvey; Salvador Moncada; Jayne Monkhouse; Daryl Rees; Linda J Russell; Rachel J Russell; Sheila Schwartz; Neil Waslidge; Richard G Knowles
Journal:  Br J Pharmacol       Date:  2005-06       Impact factor: 8.739

4.  Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis.

Authors:  Resat Cinar; Malliga R Iyer; Ziyi Liu; Zongxian Cao; Tony Jourdan; Katalin Erdelyi; Grzegorz Godlewski; Gergő Szanda; Jie Liu; Joshua K Park; Bani Mukhopadhyay; Avi Z Rosenberg; Jeih-San Liow; Robin G Lorenz; Pal Pacher; Robert B Innis; George Kunos
Journal:  JCI Insight       Date:  2016-07-21

Review 5.  Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.

Authors:  Paramita Mukherjee; Maris A Cinelli; Soosung Kang; Richard B Silverman
Journal:  Chem Soc Rev       Date:  2014-10-07       Impact factor: 54.564

6.  Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.

Authors:  Dong Zhou; Hsiaoju Lee; Justin M Rothfuss; Delphine L Chen; Datta E Ponde; Michael J Welch; Robert H Mach
Journal:  J Med Chem       Date:  2009-04-23       Impact factor: 7.446

7.  Design of benzene-1,2-diamines as selective inducible nitric oxide synthase inhibitors: a combined de novo design and docking analysis.

Authors:  Sandrea M Francis; Amit Mittal; Manishika Sharma; Prasad V Bharatam
Journal:  J Mol Model       Date:  2008-01-12       Impact factor: 1.810

8.  Role of substrate functional groups in binding to nitric oxide synthase.

Authors:  Baochen Fan; Dennis J Stuehr; Denis L Rousseau
Journal:  Biochem Biophys Res Commun       Date:  2009-02-25       Impact factor: 3.575

9.  Nitric oxide modulators: an emerging class of medicinal agents.

Authors:  S R Deshpande; K Satyanarayana; M N A Rao; K V Pai
Journal:  Indian J Pharm Sci       Date:  2012-11       Impact factor: 0.975

Review 10.  Arginine-based inhibitors of nitric oxide synthase: therapeutic potential and challenges.

Authors:  Jan Víteček; Antonín Lojek; Giuseppe Valacchi; Lukáš Kubala
Journal:  Mediators Inflamm       Date:  2012-09-04       Impact factor: 4.711
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.