Literature DB >> 10741559

Resistance-modifying agents. Part 7: 2,6-disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of alpha1-acid glycoprotein (AGP).

H C Barlow1, K J Bowman, N J Curtin, A H Calvert, B T Golding, B Huang, P J Loughlin, D R Newell, P G Smith, R J Griffin.   

Abstract

The synthesis and biological evaluation of potent 4,8-dibenzylaminopyrimidopyrimidine nucleoside transport inhibitors, with reduced binding to alpha1-acid glycoprotein, is reported.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10741559     DOI： 10.1016/s0960-894x(00)00053-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Bicyclic 6 + 6 systems: the chemistry of pyrimido[4,5-d]pyrimidines and pyrimido[5,4-d]pyrimidines.

Authors:  M Monier; Doaa Abdel-Latif; Ahmed El-Mekabaty; Khaled M Elattar
Journal:  RSC Adv       Date:  2019-09-30       Impact factor: 4.036

Review 2.  Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine scaffolds.

Authors:  Khaled M Elattar; Başak Doğru Mert; M Monier; Ahmed El-Mekabaty
Journal:  RSC Adv       Date:  2020-04-20       Impact factor: 4.036

3.  A Computational QSAR, Molecular Docking and In Vitro Cytotoxicity Study of Novel Thiouracil-Based Drugs with Anticancer Activity against Human-DNA Topoisomerase II.

Authors:  Doaa M Khaled; Mohamed E Elshakre; Mahmoud A Noamaan; Haider Butt; Marwa M Abdel Fattah; Dalia A Gaber
Journal:  Int J Mol Sci       Date:  2022-10-05       Impact factor: 6.208
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.