Literature DB >> 10741555

2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity.

C Kunick1, C Schultz, T Lemcke, D W Zaharevitz, R Gussio, R K Jalluri, E A Sausville, M Leost, L Meijer.   

Abstract

9-Trifluoromethyl-paullones with a carbon chain in the 2-position were synthesized by palladium-catalyzed coupling reactions of a 2-iodoprecursor with terminal alkenes or alkynes, respectively. The introduction of a 2-cyanoethyl substituent led to a significant enhancement of CDK1/cyclin B inhibiting property and in vitro antiproliferative activity.

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Year:  2000        PMID： 10741555     DOI： 10.1016/s0960-894x(00)00048-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

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2.  Ruthenium- and Osmium-Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity.

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3.  10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.

Authors:  Hannes Falke; Apirat Chaikuad; Anja Becker; Nadège Loaëc; Olivier Lozach; Samira Abu Jhaisha; Walter Becker; Peter G Jones; Lutz Preu; Knut Baumann; Stefan Knapp; Laurent Meijer; Conrad Kunick
Journal:  J Med Chem       Date:  2015-03-23       Impact factor: 7.446

4.  Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals.

Authors:  Ashok K Singh; Archana S Bhadauria; Umesh Kumar; Vinit Raj; Amit Rai; Pranesh Kumar; Amit K Keshari; Dinesh Kumar; Biswanath Maity; Sneha Nath; Anand Prakash; Sudipta Saha
Journal:  Sci Rep       Date:  2018-04-12       Impact factor: 4.379
  4 in total

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