| Literature DB >> 10741554 |
J Bosch1, T Roca, C G Pérez, S Montanari.
Abstract
The heterocyclic analogues of 5,6-dihydroxy-2-aminotetralins (6) were synthesized and their in vitro dopaminergic activity was compared to that of (-)-DP-5,6-ADTN and the novel potent agonist Z12571. The results show that changing the cathecol ring for a heterocycle decreases the D1-like activity of the target molecules 6. However, the D2-like activity of tetrahydroquinoline (6j) was comparable to that of (-)-DP-5,6-ADTN.Entities:
Mesh：
Substances：
Year: 2000 PMID： 10741554 DOI： 10.1016/s0960-894x(00)00049-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823