K S Kendler1, J M Myers, M C Neale. 1. Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, USA.
Abstract
OBJECTIVE: While researchers have increasing insight into the role of genetic and environmental factors in the etiology of psychiatric and substance use disorders, they know much less about how such factors influence the dimensions of healthy psychological functioning. METHOD: In a population-based sample of 794 female-female twin pairs, the authors examined, by using multivariate structural equation modeling, six dimensions of mental health: perceived physical health, nonconflictual interpersonal relationships, anxious-depressive symptoms, substance use, social support, and self-esteem. RESULTS: The best-fit model was complex and constituted five common factors (two genetic, one family environmental, and two unique environmental); variable-specific genetic effects for physical health, substance use, and social support; and variable-specific family environmental effects for interpersonal relationships and substance use. Genetic effects were seen for all six dimensions; total heritabilities ranged from 16% to 49%. Family environment was an important influence on interpersonal relationships, substance use, and social support. CONCLUSIONS: Mental health is a complex phenotype that is influenced by a diverse array of genetic and environmental factors. While genetic factors appear to be of moderate etiologic importance in all major dimensions of mental health, the family environment is an important influence on only interpersonal relations, social support, and substance use.
OBJECTIVE: While researchers have increasing insight into the role of genetic and environmental factors in the etiology of psychiatric and substance use disorders, they know much less about how such factors influence the dimensions of healthy psychological functioning. METHOD: In a population-based sample of 794 female-female twin pairs, the authors examined, by using multivariate structural equation modeling, six dimensions of mental health: perceived physical health, nonconflictual interpersonal relationships, anxious-depressive symptoms, substance use, social support, and self-esteem. RESULTS: The best-fit model was complex and constituted five common factors (two genetic, one family environmental, and two unique environmental); variable-specific genetic effects for physical health, substance use, and social support; and variable-specific family environmental effects for interpersonal relationships and substance use. Genetic effects were seen for all six dimensions; total heritabilities ranged from 16% to 49%. Family environment was an important influence on interpersonal relationships, substance use, and social support. CONCLUSIONS: Mental health is a complex phenotype that is influenced by a diverse array of genetic and environmental factors. While genetic factors appear to be of moderate etiologic importance in all major dimensions of mental health, the family environment is an important influence on only interpersonal relations, social support, and substance use.
Authors: Mirjam A G Sprangers; Jeff A Sloan; Ruut Veenhoven; Charles S Cleeland; Michele Y Halyard; Amy P Abertnethy; Frank Baas; Andrea M Barsevick; Meike Bartels; Dorret I Boomsma; Cynthia Chauhan; Amylou C Dueck; Marlene H Frost; Per Hall; Pål Klepstad; Nicholas G Martin; Christine Miaskowski; Miriam Mosing; Benjamin Movsas; Cornelis J F Van Noorden; Donald L Patrick; Nancy L Pedersen; Mary E Ropka; Quiling Shi; Gen Shinozaki; Jasvinder A Singh; Ping Yang; Ailko H Zwinderman Journal: Twin Res Hum Genet Date: 2009-06 Impact factor: 1.587