Literature DB >> 10737881

Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins.

R E Eliaz1, J Kost.   

Abstract

Physico-chemical properties of injectable polymeric implant systems, based on the principle that a water-insoluble polymer dissolved in a biocompatible solvent will precipitate upon contact with water, were studied and utilized to predict the release of proteins from these systems. Polylactide-co-glycolide copolymer (PLGA) and glycofurol were chosen since they both have pharmaceutical precedence. Changes in polymer composition, its weight percent in solution, molecular weight, and protein loading level were assessed to provide formulations with the desired release rates and duration of release. Copyright 2000 John Wiley & Sons, Inc.

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Year:  2000        PMID： 10737881     DOI： 10.1002/(sici)1097-4636(20000605)50:3<388::aid-jbm13>3.0.co;2-f

Source DB:  PubMed          Journal:  J Biomed Mater Res        ISSN： 0021-9304


  20 in total

1.  Delivery of soluble tumor necrosis factor receptor from in-situ forming PLGA implants: in-vivo.

Authors:  R E Eliaz; D Wallach; J Kost
Journal:  Pharm Res       Date:  2000-12       Impact factor: 4.200

2.  Preparation of PLGA microparticles by an emulsion-extraction process using glycofurol as polymer solvent.

Authors:  Anne Aubert-Pouëssel; Marie-Claire Venier-Julienne; Patrick Saulnier; Michelle Sergent; Jean-Pierre Benoît
Journal:  Pharm Res       Date:  2004-12       Impact factor: 4.200

Review 3.  Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends.

Authors:  J F Mano; G A Silva; H S Azevedo; P B Malafaya; R A Sousa; S S Silva; L F Boesel; J M Oliveira; T C Santos; A P Marques; N M Neves; R L Reis
Journal:  J R Soc Interface       Date:  2007-12-22       Impact factor: 4.118

4.  Novel electrohydrodynamic preparation of porous chitosan particles for drug delivery.

Authors:  Ketan Pancholi; Nassim Ahras; Eleanor Stride; Mohan Edirisinghe
Journal:  J Mater Sci Mater Med       Date:  2008-11-26       Impact factor: 3.896

Review 5.  Long-term delivery of protein therapeutics.

Authors:  Ravi Vaishya; Varun Khurana; Sulabh Patel; Ashim K Mitra
Journal:  Expert Opin Drug Deliv       Date:  2014-09-24       Impact factor: 6.648

6.  In vivo absorption of steroidal hormones from smart polymer based delivery systems.

Authors:  Sibao Chen; Daniel Pederson; Mayura Oak; Jagdish Singh
Journal:  J Pharm Sci       Date:  2010-08       Impact factor: 3.534

7.  Development of self-forming doxorubicin-loaded polymeric depots as an injectable drug delivery system for liver cancer chemotherapy.

Authors:  Pinunta Nittayacharn; Norased Nasongkla
Journal:  J Mater Sci Mater Med       Date:  2017-05-22       Impact factor: 3.896

8.  Characterization of formulation parameters affecting low molecular weight drug release from in situ forming drug delivery systems.

Authors:  Ravi B Patel; Angela N Carlson; Luis Solorio; Agata A Exner
Journal:  J Biomed Mater Res A       Date:  2010-08       Impact factor: 4.396

9.  In situ-forming pharmaceutical organogels based on the self-assembly of L-alanine derivatives.

Authors:  Anne-Claude Couffin-Hoarau; Aude Motulsky; Pascal Delmas; Jean-Christophe Leroux
Journal:  Pharm Res       Date:  2004-03       Impact factor: 4.200

10.  A novel enzymatically-mediated drug delivery carrier for bone tissue engineering applications: combining biodegradable starch-based microparticles and differentiation agents.

Authors:  Elizabeth Rosado Balmayor; Kadriye Tuzlakoglu; Alexandra P Marques; Helena S Azevedo; Rui L Reis
Journal:  J Mater Sci Mater Med       Date:  2008-01-24       Impact factor: 3.896
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